HIF-1α-Deficiency in Myeloid Cells Leads to a Disturbed Accumulation of Myeloid Derived Suppressor Cells (MDSC) During Pregnancy and to an Increased Abortion Rate in Mice

HIF-1α-Deficiency in Myeloid Cells Leads to a Disturbed Accumulation of Myeloid Derived Suppressor Cells (MDSC) During Pregnancy and to an Increased Abortion Rate in Mice

Abortions are the most important reason for unintentional childlessness. During pregnancy, maternal immune cells are in close contact to cells of the semi-allogeneic fetus. Dysregulation of the maternal immune system leading to defective adaptation to pregnancy often plays a role in pathogenesis of...

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Bibliographic Details
Main Authors: Natascha Köstlin-Gille, Stefanie Dietz, Julian Schwarz, Bärbel Spring, Jan Pauluschke-Fröhlich, Christian F. Poets, Christian Gille
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
HIF
pregnancy
MDSC
abortion
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00161/full

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