Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2
The aim of this study was to develop an amphipathic polyethylene glycol (PEG) derivative that was bi-terminally modified with celastrol and ginsenoside Rh2 (Celastrol-PEG-G Rh2). Such derivative was capable of forming novel, celastrol-loaded polymeric micelles (CG-M) for endo/lysosomal delivery and...
Main Authors: | Peng Li, XiaoYue Zhou, Ding Qu, Mengfei Guo, Chenyi Fan, Tong Zhou, Yang Ling |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2017-01-01
|
Series: | Drug Delivery |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/10717544.2017.1326540 |
Similar Items
-
Increased antitumor efficacy of ginsenoside Rh2 via mixed micelles: in vivo and in vitro evaluation
by: Xiaojing Xia, et al.
Published: (2020-01-01) -
Celastrol nanomicelles attenuate cytokine secretion in macrophages and inhibit macrophage-induced corneal neovascularization in rats
by: Li Z, et al.
Published: (2016-11-01) -
Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications
by: Dan-Dan Wang, et al.
Published: (2021-01-01) -
Biotransformation of Ginsenoside Rf to Rh1 by Recombinant β-Glucosidase
by: Yi-Nan Zheng, et al.
Published: (2009-06-01) -
A stereo-selective growth inhibition profile of ginsenoside Rh2 on human colon cancer cells
by: Yunju Jeong, et al.
Published: (2019-01-01)