TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review
During the course of evolution, multicellular organisms have been orchestrated with an efficient and versatile immune system to counteract diverse group of pathogenic organisms. Pathogen recognition is considered as the most critical step behind eliciting adequate immune response during an infection...
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doaj-cc546a25069c47e3872723f709e5df1c2020-11-25T02:49:19ZengElsevierBrazilian Journal of Infectious Diseases1413-86702016-03-01202193204S1413-86702016000200193TLR2 and TLR4 mediated host immune responses in major infectious diseases: a reviewSuprabhat Mukherjee0Subhajit Karmakar1Santi Prasad Sinha Babu2Parasitology Laboratory, Department of Zoology (Centre for Advanced Studies), Visva-Bharati University, Santiniketan, IndiaParasitology Laboratory, Department of Zoology (Centre for Advanced Studies), Visva-Bharati University, Santiniketan, IndiaCorresponding author.; Parasitology Laboratory, Department of Zoology (Centre for Advanced Studies), Visva-Bharati University, Santiniketan, IndiaDuring the course of evolution, multicellular organisms have been orchestrated with an efficient and versatile immune system to counteract diverse group of pathogenic organisms. Pathogen recognition is considered as the most critical step behind eliciting adequate immune response during an infection. Hitherto Toll-like receptors (TLRs), especially the surface ones viz. TLR2 and TLR4 have gained immense importance due to their extreme ability of identifying distinct molecular patterns from invading pathogens. These pattern recognition receptors (PRRs) not only act as innate sensor but also shape and bridge innate and adaptive immune responses. In addition, they also play a pivotal role in regulating the balance between Th1 and Th2 type of response essential for the survivability of the host. In this work, major achievements rather findings made on the typical signalling and immunopathological attributes of TLR2 and TLR4 mediated host response against the major infectious diseases have been reviewed. Infectious diseases like tuberculosis, trypanosomiasis, malaria, and filariasis are still posing myriad threat to mankind. Furthermore, increasing resistance of the causative organisms against available therapeutics is also an emerging problem. Thus, stimulation of host immune response with TLR2 and TLR4 agonist can be the option of choice to treat such diseases in future. Keywords: Toll like receptor (TLR), Trypanosomiasis, Malaria, Filariasishttp://www.sciencedirect.com/science/article/pii/S141386701500224X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suprabhat Mukherjee Subhajit Karmakar Santi Prasad Sinha Babu |
spellingShingle |
Suprabhat Mukherjee Subhajit Karmakar Santi Prasad Sinha Babu TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review Brazilian Journal of Infectious Diseases |
author_facet |
Suprabhat Mukherjee Subhajit Karmakar Santi Prasad Sinha Babu |
author_sort |
Suprabhat Mukherjee |
title |
TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review |
title_short |
TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review |
title_full |
TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review |
title_fullStr |
TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review |
title_full_unstemmed |
TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review |
title_sort |
tlr2 and tlr4 mediated host immune responses in major infectious diseases: a review |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1413-8670 |
publishDate |
2016-03-01 |
description |
During the course of evolution, multicellular organisms have been orchestrated with an efficient and versatile immune system to counteract diverse group of pathogenic organisms. Pathogen recognition is considered as the most critical step behind eliciting adequate immune response during an infection. Hitherto Toll-like receptors (TLRs), especially the surface ones viz. TLR2 and TLR4 have gained immense importance due to their extreme ability of identifying distinct molecular patterns from invading pathogens. These pattern recognition receptors (PRRs) not only act as innate sensor but also shape and bridge innate and adaptive immune responses. In addition, they also play a pivotal role in regulating the balance between Th1 and Th2 type of response essential for the survivability of the host. In this work, major achievements rather findings made on the typical signalling and immunopathological attributes of TLR2 and TLR4 mediated host response against the major infectious diseases have been reviewed. Infectious diseases like tuberculosis, trypanosomiasis, malaria, and filariasis are still posing myriad threat to mankind. Furthermore, increasing resistance of the causative organisms against available therapeutics is also an emerging problem. Thus, stimulation of host immune response with TLR2 and TLR4 agonist can be the option of choice to treat such diseases in future. Keywords: Toll like receptor (TLR), Trypanosomiasis, Malaria, Filariasis |
url |
http://www.sciencedirect.com/science/article/pii/S141386701500224X |
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