Effect of Alpha-lipoic Acid Supplementation on Serum Lipid Profile in Women with Rheumatoid Arthritis
Background and Objectives: Alpha-lipoic acid (ALA) is considered as a potent antioxidant with anti-inflammatory functions. Moreover, a number of studies have revealed its lipid lowering properties. Therefore, we aimed to examine the effect of ALA on serum lipids in women with rheumatoid arthritis (R...
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2014-09-01
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doaj-cc5ce14097b74963bdea498754897e862020-11-25T02:43:15ZengShahid Beheshti University of Medical SciencesNutrition and Food Sciences Research2283-04412383-30092014-09-01111118Effect of Alpha-lipoic Acid Supplementation on Serum Lipid Profile in Women with Rheumatoid ArthritisElham Mirtaheri0Bahram Pourghassem Gargari1Sousan Kolahi2Mohammad Asghari-Jafar-abadi3Mehrzad Hajalilou4 Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran Department of Biochemistry & Diet Therapy, Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran Associate Professor of Rheumatology, Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Assistant Professor of Road Traffic Injury Prevention Research Center, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran. Associate Professor of Rheumatology,Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Background and Objectives: Alpha-lipoic acid (ALA) is considered as a potent antioxidant with anti-inflammatory functions. Moreover, a number of studies have revealed its lipid lowering properties. Therefore, we aimed to examine the effect of ALA on serum lipids in women with rheumatoid arthritis (RA), who have high mortality rate mainly due to accelerated atherosclerosis. Materials and Methods: In the present study a total of 70 RA patients were randomly assigned into two groups (1:1) to receive either ALA (1200 mg/day) or placebo for 8 weeks. Fasting blood samples were obtained before and after the intervention to analyze serum lipid profile including triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C). International physical activity questionnaire (IPAQ) was assessed at baseline and final. Between-group comparisons were done using Student’s t-test and ANCOVA at baseline and after 8 weeks, respectively. Paired t-test was used for within-group comparisons. Sign test and Mann-Whitney’s test were used for intra- and inter-group comparisons of qualitative variables, respectively. P<0.05 was considered as significant. Results: Finally, 65 RA patients completed the trial. No statistically significant differences were observed in serum lipid levels within and between the groups before and after the study. There were no significant intra- and inter-group differences in physical activity levels at the beginning and in the end of the study. Conclusions: In the present study, serum lipid profile was not significantly affected by ALA intervention. However, ALA supplementation aiming at prevention or treatment of dyslipidemia in RA patients should be further investigated. Keywords: Lipoic acid, Supplementation, Rheumatoid arthritis, Women, Lipid profilehttp://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-225-1&slc_lang=en&sid=1Lipoic acid Supplementation Rheumatoid arthritis Women Lipid profile |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elham Mirtaheri Bahram Pourghassem Gargari Sousan Kolahi Mohammad Asghari-Jafar-abadi Mehrzad Hajalilou |
spellingShingle |
Elham Mirtaheri Bahram Pourghassem Gargari Sousan Kolahi Mohammad Asghari-Jafar-abadi Mehrzad Hajalilou Effect of Alpha-lipoic Acid Supplementation on Serum Lipid Profile in Women with Rheumatoid Arthritis Nutrition and Food Sciences Research Lipoic acid Supplementation Rheumatoid arthritis Women Lipid profile |
author_facet |
Elham Mirtaheri Bahram Pourghassem Gargari Sousan Kolahi Mohammad Asghari-Jafar-abadi Mehrzad Hajalilou |
author_sort |
Elham Mirtaheri |
title |
Effect of Alpha-lipoic Acid Supplementation on Serum Lipid Profile in Women with Rheumatoid Arthritis |
title_short |
Effect of Alpha-lipoic Acid Supplementation on Serum Lipid Profile in Women with Rheumatoid Arthritis |
title_full |
Effect of Alpha-lipoic Acid Supplementation on Serum Lipid Profile in Women with Rheumatoid Arthritis |
title_fullStr |
Effect of Alpha-lipoic Acid Supplementation on Serum Lipid Profile in Women with Rheumatoid Arthritis |
title_full_unstemmed |
Effect of Alpha-lipoic Acid Supplementation on Serum Lipid Profile in Women with Rheumatoid Arthritis |
title_sort |
effect of alpha-lipoic acid supplementation on serum lipid profile in women with rheumatoid arthritis |
publisher |
Shahid Beheshti University of Medical Sciences |
series |
Nutrition and Food Sciences Research |
issn |
2283-0441 2383-3009 |
publishDate |
2014-09-01 |
description |
Background and Objectives: Alpha-lipoic acid (ALA) is considered as a potent antioxidant with anti-inflammatory functions. Moreover, a number of studies have revealed its lipid lowering properties. Therefore, we aimed to examine the effect of ALA on serum lipids in women with rheumatoid arthritis (RA), who have high mortality rate mainly due to accelerated atherosclerosis.
Materials and Methods: In the present study a total of 70 RA patients were randomly assigned into two groups (1:1) to receive either ALA (1200 mg/day) or placebo for 8 weeks. Fasting blood samples were obtained before and after the intervention to analyze serum lipid profile including triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C). International physical activity questionnaire (IPAQ) was assessed at baseline and final. Between-group comparisons were done using Student’s t-test and ANCOVA at baseline and after 8 weeks, respectively. Paired t-test was used for within-group comparisons. Sign test and Mann-Whitney’s test were used for intra- and inter-group comparisons of qualitative variables, respectively. P<0.05 was considered as significant.
Results: Finally, 65 RA patients completed the trial. No statistically significant differences were observed in serum lipid levels within and between the groups before and after the study. There were no significant intra- and inter-group differences in physical activity levels at the beginning and in the end of the study.
Conclusions: In the present study, serum lipid profile was not significantly affected by ALA intervention. However, ALA supplementation aiming at prevention or treatment of dyslipidemia in RA patients should be further investigated.
Keywords: Lipoic acid, Supplementation, Rheumatoid arthritis, Women, Lipid profile |
topic |
Lipoic acid Supplementation Rheumatoid arthritis Women Lipid profile |
url |
http://nfsr.sbmu.ac.ir/browse.php?a_code=A-10-225-1&slc_lang=en&sid=1 |
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