Lck mediates signal transmission from CD59 to the TCR/CD3 pathway in Jurkat T cells.

Lck mediates signal transmission from CD59 to the TCR/CD3 pathway in Jurkat T cells.

The glycosylphosphatidylinositol (GPI)-anchored molecule CD59 has been implicated in the modulation of T cell responses, but the underlying molecular mechanism of CD59 influencing T cell signaling remained unclear. Here we analyzed Jurkat T cells stimulated via anti-CD3ε- or anti-CD59-coated surface...

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Bibliographic Details
Main Authors: Anna M Lipp, Kata Juhasz, Christian Paar, Christoph Ogris, Paul Eckerstorfer, Roland Thuenauer, Jan Hesse, Benedikt Nimmervoll, Hannes Stockinger, Gerhard J Schütz, Ulrich Bodenhofer, Zsolt Balogi, Alois Sonnleitner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3893272?pdf=render

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