Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives
Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effect...
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doaj-cc60ddbf4b9141a6a569ec14bd0a23342020-11-24T21:42:00ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-10-011410205082054210.3390/ijms141020508Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New PerspectivesGuillaume BronsardClaire FougerouMichel BotbolSophie RibardiereEnas LagdasSolenn KermarrecRémi FagardOlivier SchischmanoffNemat JaafariDavid CohenMarianne BarburothGeorge M. AndersonImen NajjarEric BellissantJulie Vernay-LeconteSylvie TordjmanAbnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism. In addition, melatonin, as a pineal gland hormone produced from serotonin, is of special interest in autistic disorder given reported alterations in central and peripheral serotonin neurobiology. More specifically, the role of melatonin in the ontogenetic establishment of circadian rhythms and the synchronization of peripheral oscillators opens interesting perspectives to ascertain better the mechanisms underlying the significant relationship found between lower nocturnal melatonin excretion and increased severity of autistic social communication impairments, especially for verbal communication and social imitative play. In this article, first we review the studies on melatonin levels and the treatment studies of melatonin in autistic disorder. Then, we discuss the relationships between melatonin and autistic behavioral impairments with regard to social communication (verbal and non-verbal communication, social interaction), and repetitive behaviors or interests with difficulties adapting to change. In conclusion, we emphasize that randomized clinical trials in autism spectrum disorders are warranted to establish potential therapeutic efficacy of melatonin for social communication impairments and stereotyped behaviors or interests.http://www.mdpi.com/1422-0067/14/10/20508melatoninbiological clockscircadian rhythmsynchronyautism spectrum disorderssocial communicationstereotyped behaviors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guillaume Bronsard Claire Fougerou Michel Botbol Sophie Ribardiere Enas Lagdas Solenn Kermarrec Rémi Fagard Olivier Schischmanoff Nemat Jaafari David Cohen Marianne Barburoth George M. Anderson Imen Najjar Eric Bellissant Julie Vernay-Leconte Sylvie Tordjman |
spellingShingle |
Guillaume Bronsard Claire Fougerou Michel Botbol Sophie Ribardiere Enas Lagdas Solenn Kermarrec Rémi Fagard Olivier Schischmanoff Nemat Jaafari David Cohen Marianne Barburoth George M. Anderson Imen Najjar Eric Bellissant Julie Vernay-Leconte Sylvie Tordjman Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives International Journal of Molecular Sciences melatonin biological clocks circadian rhythm synchrony autism spectrum disorders social communication stereotyped behaviors |
author_facet |
Guillaume Bronsard Claire Fougerou Michel Botbol Sophie Ribardiere Enas Lagdas Solenn Kermarrec Rémi Fagard Olivier Schischmanoff Nemat Jaafari David Cohen Marianne Barburoth George M. Anderson Imen Najjar Eric Bellissant Julie Vernay-Leconte Sylvie Tordjman |
author_sort |
Guillaume Bronsard |
title |
Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives |
title_short |
Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives |
title_full |
Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives |
title_fullStr |
Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives |
title_full_unstemmed |
Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives |
title_sort |
advances in the research of melatonin in autism spectrum disorders: literature review and new perspectives |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2013-10-01 |
description |
Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism. In addition, melatonin, as a pineal gland hormone produced from serotonin, is of special interest in autistic disorder given reported alterations in central and peripheral serotonin neurobiology. More specifically, the role of melatonin in the ontogenetic establishment of circadian rhythms and the synchronization of peripheral oscillators opens interesting perspectives to ascertain better the mechanisms underlying the significant relationship found between lower nocturnal melatonin excretion and increased severity of autistic social communication impairments, especially for verbal communication and social imitative play. In this article, first we review the studies on melatonin levels and the treatment studies of melatonin in autistic disorder. Then, we discuss the relationships between melatonin and autistic behavioral impairments with regard to social communication (verbal and non-verbal communication, social interaction), and repetitive behaviors or interests with difficulties adapting to change. In conclusion, we emphasize that randomized clinical trials in autism spectrum disorders are warranted to establish potential therapeutic efficacy of melatonin for social communication impairments and stereotyped behaviors or interests. |
topic |
melatonin biological clocks circadian rhythm synchrony autism spectrum disorders social communication stereotyped behaviors |
url |
http://www.mdpi.com/1422-0067/14/10/20508 |
work_keys_str_mv |
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