Validation of Gene Therapy for Mutant Mitochondria by Delivering Mitochondrial RNA Using a MITO-Porter
Here, we report on validating a mitochondrial gene therapy by delivering nucleic acids to mitochondria of diseased cells by a MITO-Porter, a liposome-based carrier for mitochondrial delivery. We used cells derived from a patient with a mitochondrial disease with a G625A heteroplasmic mutation in the...
Main Authors: | Eriko Kawamura, Minako Maruyama, Jiro Abe, Akira Sudo, Atsuhito Takeda, Shingo Takada, Takashi Yokota, Shintaro Kinugawa, Hideyoshi Harashima, Yuma Yamada |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-06-01
|
Series: | Molecular Therapy: Nucleic Acids |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253120301128 |
Similar Items
-
Challenges in Promoting Mitochondrial Transplantation Therapy
by: Yuma Yamada, et al.
Published: (2020-09-01) -
Functional Mitochondria in Health and Disease
by: Patries M. Herst, et al.
Published: (2017-11-01) -
Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery
by: Alexander J Sercel, et al.
Published: (2021-01-01) -
Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress
by: Yuma Yamada, et al.
Published: (2020-01-01) -
Condensation of Plasmid DNA Enhances Mitochondrial Association in Skeletal Muscle Following Hydrodynamic Limb Vein Injection
by: Yukari Yasuzaki, et al.
Published: (2014-08-01)