Structure of Supramers Formed by the Amphiphile Biotin‐CMG‐DOPE

• Main Authors: Dr. Anton Zalygin, Dr. Daria Solovyeva, Ivan Vaskan, Dr. Stephen Henry, Dr. Marcel Schaefer, Dr. Pavel Volynsky, Dr. Alexander Tuzikov, Dr. Elena Korchagina, Dr. Ivan Ryzhov, Dr. Alexey Nizovtsev, Dr. Konstantin Mochalov, Prof. Roman Efremov, Dr. Eleonora Shtykova, Dr. Vladimir Oleinikov, Prof. Nicolai Bovin
• Format: Article
• Language: English
• Published: Wiley-VCH 2020-06-01
• Series: ChemistryOpen
• Online Access: https://doi.org/10.1002/open.202000139

Abstract Invited for this month's cover is the group of Prof. Nicolai Bovin from the Russian Academy of Sciences. The cover picture shows how a biotin residue initially hidden in a monolayer formed on the surface of a material by biot‐CMG‐DOPE (see top left) is pulled out of the layer by the streptavidin molecule (Str) that has come close to it (see below). This can be considered as a model of certain events (in particular, cis protein‐ligand interactions) occurring on the surface of a living cell when it is necessary to hide the ligand from undesirable interactions, but leave the possibility of its recognition by a high‐affinity protein. The picture is inspired by the legendary Yellow Submarine cartoon. Read the full text of their Full Paper at 10.1002/open.201900276.