Vitamin D in inflammatory diseases
Changes in vitamin D serum levels have been associated with inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, atherosclerosis or asthma. Genome- and transcriptome-wide studies indicate that vitamin D signalling modulate...
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doaj-cc79c00448e5457cb9d9fa04c6fd0c582020-11-24T23:04:29ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-07-01510.3389/fphys.2014.0024497223Vitamin D in inflammatory diseasesThea K Wöbke0Bernd L Sorg1Dieter eSteinhilber2Goethe UniversitatGoethe UniversitatGoethe UniversitatChanges in vitamin D serum levels have been associated with inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, atherosclerosis or asthma. Genome- and transcriptome-wide studies indicate that vitamin D signalling modulates many inflammatory responses on several levels. This includes i) the regulation of the expression of genes which generate pro-inflammatory mediators, such as cyclooxygenases or 5-lipoxygenase, ii) the interference with transcription factors, such as NF-kB, which regulate the expression of inflammatory genes and iii) the activation of signalling cascades, such as MAP kinases which mediate inflammatory responses. Vitamin D targets various tissues and cell types, a number of which belong to the immune system, such as monocytes/macrophages, dendritic cells as well as B- and T cells, leading to individual responses of each cell type. One hallmark of these specific vitamin D effects is the cell-type specific regulation of genes involved in the regulation of inflammatory processes and the interplay between vitamin D signalling and other signalling cascades involved in inflammation.An important task in the near future will be the elucidation of the regulatory mechanisms that are involved in the regulation of inflammatory responses by vitamin D on the molecular level by the use of techniques such as chromatin immunoprecipitation (ChIP), ChIP-seq and FAIRE-seq.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00244/fullInterleukinsInnate immune systemNFkBcyclooxygenaseNFATVDR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thea K Wöbke Bernd L Sorg Dieter eSteinhilber |
spellingShingle |
Thea K Wöbke Bernd L Sorg Dieter eSteinhilber Vitamin D in inflammatory diseases Frontiers in Physiology Interleukins Innate immune system NFkB cyclooxygenase NFAT VDR |
author_facet |
Thea K Wöbke Bernd L Sorg Dieter eSteinhilber |
author_sort |
Thea K Wöbke |
title |
Vitamin D in inflammatory diseases |
title_short |
Vitamin D in inflammatory diseases |
title_full |
Vitamin D in inflammatory diseases |
title_fullStr |
Vitamin D in inflammatory diseases |
title_full_unstemmed |
Vitamin D in inflammatory diseases |
title_sort |
vitamin d in inflammatory diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2014-07-01 |
description |
Changes in vitamin D serum levels have been associated with inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, atherosclerosis or asthma. Genome- and transcriptome-wide studies indicate that vitamin D signalling modulates many inflammatory responses on several levels. This includes i) the regulation of the expression of genes which generate pro-inflammatory mediators, such as cyclooxygenases or 5-lipoxygenase, ii) the interference with transcription factors, such as NF-kB, which regulate the expression of inflammatory genes and iii) the activation of signalling cascades, such as MAP kinases which mediate inflammatory responses. Vitamin D targets various tissues and cell types, a number of which belong to the immune system, such as monocytes/macrophages, dendritic cells as well as B- and T cells, leading to individual responses of each cell type. One hallmark of these specific vitamin D effects is the cell-type specific regulation of genes involved in the regulation of inflammatory processes and the interplay between vitamin D signalling and other signalling cascades involved in inflammation.An important task in the near future will be the elucidation of the regulatory mechanisms that are involved in the regulation of inflammatory responses by vitamin D on the molecular level by the use of techniques such as chromatin immunoprecipitation (ChIP), ChIP-seq and FAIRE-seq. |
topic |
Interleukins Innate immune system NFkB cyclooxygenase NFAT VDR |
url |
http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00244/full |
work_keys_str_mv |
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