Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces
Cystoid spaces (CSs) are a common retinal finding in choroideremia (CHM) patients. The aim of this study was to analyze the vascular features of the choroid associated with the presence of CSs in patients with confirmed genetic diagnosis of CHM. A total of 33 patients (33 eyes) were enrolled in this...
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doaj-cc7a1f26be3b409192bd96ad0719ac512021-02-25T00:02:55ZengMDPI AGDiagnostics2075-44182021-02-011138238210.3390/diagnostics11030382Choroidal Vascularity Features in Patients with Choroideremia and Cystoid SpacesClaudio Iovino0Valentina Di Iorio1Francesco Testa2Viviana Bombace3Paolo Melillo4Kiran Kumar Vupparaboina5Jay Chhablani6Francesca Simonelli7Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania ‘Luigi Vanvitelli’, via Pansini 5, 80131 Naples, ItalyEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania ‘Luigi Vanvitelli’, via Pansini 5, 80131 Naples, ItalyEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania ‘Luigi Vanvitelli’, via Pansini 5, 80131 Naples, ItalyEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania ‘Luigi Vanvitelli’, via Pansini 5, 80131 Naples, ItalyEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania ‘Luigi Vanvitelli’, via Pansini 5, 80131 Naples, ItalySmt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad 500034, IndiaDepartment of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USAEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania ‘Luigi Vanvitelli’, via Pansini 5, 80131 Naples, ItalyCystoid spaces (CSs) are a common retinal finding in choroideremia (CHM) patients. The aim of this study was to analyze the vascular features of the choroid associated with the presence of CSs in patients with confirmed genetic diagnosis of CHM. A total of 33 patients (33 eyes) were enrolled in this retrospective cross-sectional study and divided into two groups based on the presence (17 eyes) or absence (16 eyes) of CSs. Choroidal features were evaluated on spectral-domain optical coherence tomography including subfoveal choroidal thickness (CT), total choroidal area (TCA), luminal choroidal area (LCA), and stromal choroidal area (SCA). The choroidal vascularity index (CVI) was then calculated in all study eyes. All structural choroidal parameters were calculated both on the entire length of the B-scan and in the central subfoveal 1500 μm. The average age was 37.3 ± 11.6 and 31.4 ± 16.7 years (<i>p </i>= 0.25) and mean logMAR best-corrected visual acuity was 0.11 ± 0.20 and 0.20 ± 0.57 (<i>p </i>= 0.54) in the CHM groups with and without CSs, respectively. There were no significant differences in subfoveal CT, and TCA, LCA, SCA, and CVI evaluated on either the entire scan or in the central 1500 μm (all <i>p </i>> 0.05). All choroidal vasculature parameters exhibited no significant differences between CHM eyes with and without CSs. Our results suggest that the choroid may not be involved in the development of CSs in patients with CHM.https://www.mdpi.com/2075-4418/11/3/382choroidal vascularity indexchoroideremiacystoid macular edemacystoid space. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudio Iovino Valentina Di Iorio Francesco Testa Viviana Bombace Paolo Melillo Kiran Kumar Vupparaboina Jay Chhablani Francesca Simonelli |
spellingShingle |
Claudio Iovino Valentina Di Iorio Francesco Testa Viviana Bombace Paolo Melillo Kiran Kumar Vupparaboina Jay Chhablani Francesca Simonelli Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces Diagnostics choroidal vascularity index choroideremia cystoid macular edema cystoid space. |
author_facet |
Claudio Iovino Valentina Di Iorio Francesco Testa Viviana Bombace Paolo Melillo Kiran Kumar Vupparaboina Jay Chhablani Francesca Simonelli |
author_sort |
Claudio Iovino |
title |
Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces |
title_short |
Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces |
title_full |
Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces |
title_fullStr |
Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces |
title_full_unstemmed |
Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces |
title_sort |
choroidal vascularity features in patients with choroideremia and cystoid spaces |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2021-02-01 |
description |
Cystoid spaces (CSs) are a common retinal finding in choroideremia (CHM) patients. The aim of this study was to analyze the vascular features of the choroid associated with the presence of CSs in patients with confirmed genetic diagnosis of CHM. A total of 33 patients (33 eyes) were enrolled in this retrospective cross-sectional study and divided into two groups based on the presence (17 eyes) or absence (16 eyes) of CSs. Choroidal features were evaluated on spectral-domain optical coherence tomography including subfoveal choroidal thickness (CT), total choroidal area (TCA), luminal choroidal area (LCA), and stromal choroidal area (SCA). The choroidal vascularity index (CVI) was then calculated in all study eyes. All structural choroidal parameters were calculated both on the entire length of the B-scan and in the central subfoveal 1500 μm. The average age was 37.3 ± 11.6 and 31.4 ± 16.7 years (<i>p </i>= 0.25) and mean logMAR best-corrected visual acuity was 0.11 ± 0.20 and 0.20 ± 0.57 (<i>p </i>= 0.54) in the CHM groups with and without CSs, respectively. There were no significant differences in subfoveal CT, and TCA, LCA, SCA, and CVI evaluated on either the entire scan or in the central 1500 μm (all <i>p </i>> 0.05). All choroidal vasculature parameters exhibited no significant differences between CHM eyes with and without CSs. Our results suggest that the choroid may not be involved in the development of CSs in patients with CHM. |
topic |
choroidal vascularity index choroideremia cystoid macular edema cystoid space. |
url |
https://www.mdpi.com/2075-4418/11/3/382 |
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