Contextual dependencies expand the re-usability of genetic inverters

Contextual dependencies expand the re-usability of genetic inverters

Genetic circuits can be engineered to generate predefined outcomes, however host context is a crucial factor in performance. Here the authors characterise twenty NOT gates in seven different bacteria to understand and predict interoperability and portability across hosts.

Bibliographic Details
Main Authors: Huseyin Tas, Lewis Grozinger, Ruud Stoof, Victor de Lorenzo, Ángel Goñi-Moreno
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20656-5
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spelling doaj-cc80afe3b1d048be9b7194d29717c1e42021-01-17T12:12:18ZengNature Publishing GroupNature Communications2041-17232021-01-011211910.1038/s41467-020-20656-5Contextual dependencies expand the re-usability of genetic invertersHuseyin Tas0Lewis Grozinger1Ruud Stoof2Victor de Lorenzo3Ángel Goñi-Moreno4Systems Biology Department, Centro Nacional de Biotecnologia-CSICSchool of Computing, Newcastle UniversitySchool of Computing, Newcastle UniversitySystems Biology Department, Centro Nacional de Biotecnologia-CSICSchool of Computing, Newcastle UniversityGenetic circuits can be engineered to generate predefined outcomes, however host context is a crucial factor in performance. Here the authors characterise twenty NOT gates in seven different bacteria to understand and predict interoperability and portability across hosts.https://doi.org/10.1038/s41467-020-20656-5
collection DOAJ
language English
format Article
sources DOAJ
author Huseyin Tas
Lewis Grozinger
Ruud Stoof
Victor de Lorenzo
Ángel Goñi-Moreno
spellingShingle Huseyin Tas
Lewis Grozinger
Ruud Stoof
Victor de Lorenzo
Ángel Goñi-Moreno
Contextual dependencies expand the re-usability of genetic inverters
Nature Communications
author_facet Huseyin Tas
Lewis Grozinger
Ruud Stoof
Victor de Lorenzo
Ángel Goñi-Moreno
author_sort Huseyin Tas
title Contextual dependencies expand the re-usability of genetic inverters
title_short Contextual dependencies expand the re-usability of genetic inverters
title_full Contextual dependencies expand the re-usability of genetic inverters
title_fullStr Contextual dependencies expand the re-usability of genetic inverters
title_full_unstemmed Contextual dependencies expand the re-usability of genetic inverters
title_sort contextual dependencies expand the re-usability of genetic inverters
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description Genetic circuits can be engineered to generate predefined outcomes, however host context is a crucial factor in performance. Here the authors characterise twenty NOT gates in seven different bacteria to understand and predict interoperability and portability across hosts.
url https://doi.org/10.1038/s41467-020-20656-5
work_keys_str_mv AT huseyintas contextualdependenciesexpandthereusabilityofgeneticinverters
AT lewisgrozinger contextualdependenciesexpandthereusabilityofgeneticinverters
AT ruudstoof contextualdependenciesexpandthereusabilityofgeneticinverters
AT victordelorenzo contextualdependenciesexpandthereusabilityofgeneticinverters
AT angelgonimoreno contextualdependenciesexpandthereusabilityofgeneticinverters
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