Dosimetry of permanent interstitial prostate brachytherapy for an intraoperative procedure, using O-arm based CT and TRUS
Purpose: The aim of this report is dosimetric evaluation for an intraoperative fusion computed tomography (CT) as a superior predictor of 1-month CT based dosimetry in comparison to transrectal ultrasound (TRUS) in permanent interstitial prostate brachytherapy. Material and methods : Data of 65...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Termedia Publishing House
2016-02-01
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Series: | Journal of Contemporary Brachytherapy |
Subjects: | |
Online Access: | https://www.termedia.pl/Dosimetry-of-permanent-interstitial-prostate-brachytherapy-for-an-intraoperative-procedure-using-O-arm-based-CT-and-TRUS,54,26936,1,1.html |
Summary: | Purpose: The aim of this report is dosimetric evaluation for an intraoperative fusion computed tomography (CT) as a superior predictor of 1-month CT based dosimetry in comparison to transrectal ultrasound (TRUS) in permanent interstitial prostate brachytherapy.
Material and methods : Data of 65 patients treated with seed implantation were analyzed. All procedures has been performed with patients in the lithotomy position inside the O-arm system. An end-fine probe is used as a landmark to fuse TRUS and O-arm-based CT images. There was no difference in the patient’s position, probe position, and timing of image acquisition between the two imaging modalities. Dose-volume histogram (DVH) parameters such as the dose to 90% of prostate volume (D 90 ) has been analyzed.
Results: The area under the curve of the receiver operating characteristic tended to be larger on fusion CT than on TRUS for most DVH parameters (71.85% vs. 59.59% for D 90 ; p = 0.07). Significant relationships between fusion CT and 1-month CT were confirmed using Pearson’s correlation coefficients for most DVH parameters (R = 0.48, p < 0.01 for D 90 ), although the relationship between TRUS and 1-month CT was poor. Large dose reduction (35 Gy for D 90 ) was seen from TRUS to fusion CT, especially in patients with high body weight and small prostate volume.
Conclusions : Intraoperative fusion CT appears to have higher predictive power for 1-month CT-based dosimetry than TRUS. A prospective trial using fusion CT-based planning is warranted. |
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ISSN: | 1689-832X 2081-2841 |