In vitro and in vivo antitumor activity of a novel pH-activated polymeric drug delivery system for doxorubicin.
<h4>Background</h4>Conventional chemotherapy agent such as doxorubicin (DOX) is of limited clinical use because of its inherently low selectivity, which can lead to systemic toxicity in normal healthy tissue.<h4>Methods</h4>A pH stimuli-sensitive conjugate based on polyethyle...
Main Authors: | Menglei Huan, Bangle Zhang, Zenghui Teng, Han Cui, Jieping Wang, Xinyou Liu, Hui Xia, Siyuan Zhou, Qibing Mei |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028490/?tool=EBI |
Similar Items
-
Deposition of Doxorubicin in Rats following Administration of Three Newly Synthesized Doxorubicin Conjugates
by: Menglei Huan, et al.
Published: (2013-01-01) -
Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin
by: Chunyun Wang, et al.
Published: (2020-01-01) -
Mitochondria-targeted delivery of doxorubicin to enhance antitumor activity with HER-2 peptide-mediated multifunctional pH-sensitive DQAsomes
by: Shi M, et al.
Published: (2018-07-01) -
Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride
by: Sahar Mohamaddoust Aliabadi, et al.
Published: (2015-07-01) -
Doxorubicin-loaded pH-sensitive micelles: A promising alternative to enhance antitumor activity and reduce toxicity
by: Carolina Henriques Cavalcante, et al.
Published: (2021-02-01)