Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial Fibrillation
Background: Current evidence links atrial fibrillation (AF) to the inflammation. Inflammatory indexes such as high-sensitive C-reactive protein (hs-CRP) have been related to the development and persistence of AF. However, the role of inflammation in the atrial electrophysiological remodeling indexed...
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doaj-cc96d6d1adc44addb98fd04a84b690902020-11-25T00:45:02ZengWolters KluwerChinese Medical Journal0366-69992015-01-01128111450145410.4103/0366-6999.157649Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial FibrillationLi-Hui ZhengYan YaoLing-Min WuKui-Jun ZhangShu ZhangBackground: Current evidence links atrial fibrillation (AF) to the inflammation. Inflammatory indexes such as high-sensitive C-reactive protein (hs-CRP) have been related to the development and persistence of AF. However, the role of inflammation in the atrial electrophysiological remodeling indexed by P-wave dispersion (P d ) remains unclear. Methods: The study consisted of 71 patients with lone paroxysmal AF (AF group) and 71 age- and gender-matched controls of paroxysmal supraventricular tachycardia without history of AF (control group). Electrocardiography, P d , hs-CRP, and other clinical characteristics were compared between the two groups. Results: There was no significant difference between the two groups regarding age, gender, hyperlipidemia, etc. Compared to controls, left atrial diameter (44 ± 7 vs 39 ± 7 mm), P d (49 ± 13 vs 26 ± 8 ms), and hs-CRP (2.17 [1.46-2.89] vs 1.12 [0.74-1.41] mg/L) were increased (P < 0.05), respectively. Linear regression identified hs-CRP as an independent correlation of P d level both in the total population and the AF group (r = 0.464 and 0.313; P < 0.001, respectively). Multiple logistic regression revealed hs-CRP as an independent determinant of AF (odds ratio [OR] =15.430, 95% confidence interval: 6.031-39.476: P <0.001). Further adjusted for P d , both P d and hs-CRP were independent predictors for AF, but the OR for hs-CRP in predicting AF has been attenuated from 15.430 to 6.246. Conclusions: In lone AF, P d and plasma hs-CRP concentration are inter-associated and related to AF. The interaction between hs-CRP and AF may be mediated by P d , suggesting an important role of inflammation in the atrial electrophysiological remodeling predisposing to AF.http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=11;spage=1450;epage=1454;aulast=ZhengAtrial Fibrillation; High-sensitive C-reactive Protein; Inflammation; P-wave Dispersion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li-Hui Zheng Yan Yao Ling-Min Wu Kui-Jun Zhang Shu Zhang |
spellingShingle |
Li-Hui Zheng Yan Yao Ling-Min Wu Kui-Jun Zhang Shu Zhang Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial Fibrillation Chinese Medical Journal Atrial Fibrillation; High-sensitive C-reactive Protein; Inflammation; P-wave Dispersion |
author_facet |
Li-Hui Zheng Yan Yao Ling-Min Wu Kui-Jun Zhang Shu Zhang |
author_sort |
Li-Hui Zheng |
title |
Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial Fibrillation |
title_short |
Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial Fibrillation |
title_full |
Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial Fibrillation |
title_fullStr |
Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial Fibrillation |
title_full_unstemmed |
Relationships of High-sensitive C-reactive Protein and P-wave Dispersion in Lone Atrial Fibrillation |
title_sort |
relationships of high-sensitive c-reactive protein and p-wave dispersion in lone atrial fibrillation |
publisher |
Wolters Kluwer |
series |
Chinese Medical Journal |
issn |
0366-6999 |
publishDate |
2015-01-01 |
description |
Background: Current evidence links atrial fibrillation (AF) to the inflammation. Inflammatory indexes such as high-sensitive C-reactive protein (hs-CRP) have been related to the development and persistence of AF. However, the role of inflammation in the atrial electrophysiological remodeling indexed by P-wave dispersion (P d ) remains unclear.
Methods: The study consisted of 71 patients with lone paroxysmal AF (AF group) and 71 age- and gender-matched controls of paroxysmal supraventricular tachycardia without history of AF (control group). Electrocardiography, P d , hs-CRP, and other clinical characteristics were compared between the two groups.
Results: There was no significant difference between the two groups regarding age, gender, hyperlipidemia, etc. Compared to controls, left atrial diameter (44 ± 7 vs 39 ± 7 mm), P d (49 ± 13 vs 26 ± 8 ms), and hs-CRP (2.17 [1.46-2.89] vs 1.12 [0.74-1.41] mg/L) were increased (P < 0.05), respectively. Linear regression identified hs-CRP as an independent correlation of P d level both in the total population and the AF group (r = 0.464 and 0.313; P < 0.001, respectively). Multiple logistic regression revealed hs-CRP as an independent determinant of AF (odds ratio [OR] =15.430, 95% confidence interval: 6.031-39.476: P <0.001). Further adjusted for P d , both P d and hs-CRP were independent predictors for AF, but the OR for hs-CRP in predicting AF has been attenuated from 15.430 to 6.246.
Conclusions: In lone AF, P d and plasma hs-CRP concentration are inter-associated and related to AF. The interaction between hs-CRP and AF may be mediated by P d , suggesting an important role of inflammation in the atrial electrophysiological remodeling predisposing to AF. |
topic |
Atrial Fibrillation; High-sensitive C-reactive Protein; Inflammation; P-wave Dispersion |
url |
http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=11;spage=1450;epage=1454;aulast=Zheng |
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