IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope.
The immunoglobulins expressed by chronic lymphocytic leukemia (CLL) B cells are highly restricted, suggesting they are selected for binding either self or foreign antigen. Of the immunoglobulin heavy-chain variable (IGHV) genes expressed in CLL, IGHV1-69 is the most common, and often is expressed wi...
Main Authors: | Xuchu Que, George F Widhopf, Shahzada Amir, Karsten Hartvigsen, Lotte F Hansen, Douglas Woelkers, Sotirios Tsimikas, Christoph J Binder, Thomas J Kipps, Joseph L Witztum |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3688726?pdf=render |
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