Changes in Subcellular Localization of Host Proteins Induced by Plant Viruses
Viruses are dependent on host factors at all parts of the infection cycle, such as translation, genome replication, encapsidation, and cell-to-cell and systemic movement. RNA viruses replicate their genome in compartments associated with the endoplasmic reticulum, chloroplasts, and mitochondria or p...
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doaj-cc992e435c31495f85bd1d5ab0d14ffc2021-04-15T23:02:53ZengMDPI AGViruses1999-49152021-04-011367767710.3390/v13040677Changes in Subcellular Localization of Host Proteins Induced by Plant VirusesRosalba Rodriguez-Peña0Kaoutar El Mounadi1Hernan Garcia-Ruiz2Department of Plant Pathology, Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68503, USADepartment of Biology, Kutztown University of Pennsylvania, Kutztown, PA 19530, USADepartment of Plant Pathology, Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68503, USAViruses are dependent on host factors at all parts of the infection cycle, such as translation, genome replication, encapsidation, and cell-to-cell and systemic movement. RNA viruses replicate their genome in compartments associated with the endoplasmic reticulum, chloroplasts, and mitochondria or peroxisome membranes. In contrast, DNA viruses replicate in the nucleus. Viral infection causes changes in plant gene expression and in the subcellular localization of some host proteins. These changes may support or inhibit virus accumulation and spread. Here, we review host proteins that change their subcellular localization in the presence of a plant virus. The most frequent change is the movement of host cytoplasmic proteins into the sites of virus replication through interactions with viral proteins, and the protein contributes to essential viral processes. In contrast, only a small number of studies document changes in the subcellular localization of proteins with antiviral activity. Understanding the changes in the subcellular localization of host proteins during plant virus infection provides novel insights into the mechanisms of plant–virus interactions and may help the identification of targets for designing genetic resistance to plant viruses.https://www.mdpi.com/1999-4915/13/4/677antiviralcolocalizationhost factorsprotein relocalizationproviralreplication proteins |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosalba Rodriguez-Peña Kaoutar El Mounadi Hernan Garcia-Ruiz |
spellingShingle |
Rosalba Rodriguez-Peña Kaoutar El Mounadi Hernan Garcia-Ruiz Changes in Subcellular Localization of Host Proteins Induced by Plant Viruses Viruses antiviral colocalization host factors protein relocalization proviral replication proteins |
author_facet |
Rosalba Rodriguez-Peña Kaoutar El Mounadi Hernan Garcia-Ruiz |
author_sort |
Rosalba Rodriguez-Peña |
title |
Changes in Subcellular Localization of Host Proteins Induced by Plant Viruses |
title_short |
Changes in Subcellular Localization of Host Proteins Induced by Plant Viruses |
title_full |
Changes in Subcellular Localization of Host Proteins Induced by Plant Viruses |
title_fullStr |
Changes in Subcellular Localization of Host Proteins Induced by Plant Viruses |
title_full_unstemmed |
Changes in Subcellular Localization of Host Proteins Induced by Plant Viruses |
title_sort |
changes in subcellular localization of host proteins induced by plant viruses |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2021-04-01 |
description |
Viruses are dependent on host factors at all parts of the infection cycle, such as translation, genome replication, encapsidation, and cell-to-cell and systemic movement. RNA viruses replicate their genome in compartments associated with the endoplasmic reticulum, chloroplasts, and mitochondria or peroxisome membranes. In contrast, DNA viruses replicate in the nucleus. Viral infection causes changes in plant gene expression and in the subcellular localization of some host proteins. These changes may support or inhibit virus accumulation and spread. Here, we review host proteins that change their subcellular localization in the presence of a plant virus. The most frequent change is the movement of host cytoplasmic proteins into the sites of virus replication through interactions with viral proteins, and the protein contributes to essential viral processes. In contrast, only a small number of studies document changes in the subcellular localization of proteins with antiviral activity. Understanding the changes in the subcellular localization of host proteins during plant virus infection provides novel insights into the mechanisms of plant–virus interactions and may help the identification of targets for designing genetic resistance to plant viruses. |
topic |
antiviral colocalization host factors protein relocalization proviral replication proteins |
url |
https://www.mdpi.com/1999-4915/13/4/677 |
work_keys_str_mv |
AT rosalbarodriguezpena changesinsubcellularlocalizationofhostproteinsinducedbyplantviruses AT kaoutarelmounadi changesinsubcellularlocalizationofhostproteinsinducedbyplantviruses AT hernangarciaruiz changesinsubcellularlocalizationofhostproteinsinducedbyplantviruses |
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1721525950349312000 |