Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma
Abstract Background In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression was inversely correlated with patient survival. The aim of the study was...
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doaj-ccab7eacb78948ca8b95c8a0a5daec962020-11-24T22:00:06ZengBMCBMC Cancer1471-24072018-11-011811610.1186/s12885-018-5013-2Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinomaDingyuan Hu0Daniel Ansari1Qimin Zhou2Agata Sasor3Katarzyna Said Hilmersson4Monika Bauden5Yi Jiang6Roland Andersson7Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University HospitalDepartment of Surgery, Clinical Sciences Lund, Lund University and Skåne University HospitalDepartment of Surgery, Clinical Sciences Lund, Lund University and Skåne University HospitalDepartment of Pathology, Skåne University HospitalDepartment of Surgery, Clinical Sciences Lund, Lund University and Skåne University HospitalDepartment of Surgery, Clinical Sciences Lund, Lund University and Skåne University HospitalDepartment of Gastroenterology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Surgery, Clinical Sciences Lund, Lund University and Skåne University HospitalAbstract Background In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression was inversely correlated with patient survival. The aim of the study was to further validate the prognostic significance of CLCA1 in pancreatic cancer. Methods CLCA1 expression was evaluated with tissue microarrays and immunohistochemistry in 140 patients with pancreatic ductal adenocarcinoma that underwent surgical resection at Skåne University Hospital, Sweden. Kaplan-Meier and Cox proportional hazards modeling were used to explore the association between CLCA1 and clinicopathological factors and survival. Results CLCA1 expression was denoted as positive in 90 tumors (64.3%), with positive staining being limited to the tumor cells. There were no significant association between CLCA1 expression and established clinicopathological parameters. Low CLCA1 expression correlated significantly with shorter disease-free survival (11.9 vs 17.5 months, P = 0.042). Multivariable Cox regression analysis confirmed the results (HR 0.61, 95% CI-0.40-0.92, P = 0.019). Conclusions Low CLCA1 expression is an independent factor of poor disease-free survival in pancreatic cancer.http://link.springer.com/article/10.1186/s12885-018-5013-2Pancreatic ductal adenocarcinomaCLCA1Calcium-activated chloride channel regulatorsSurvival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dingyuan Hu Daniel Ansari Qimin Zhou Agata Sasor Katarzyna Said Hilmersson Monika Bauden Yi Jiang Roland Andersson |
spellingShingle |
Dingyuan Hu Daniel Ansari Qimin Zhou Agata Sasor Katarzyna Said Hilmersson Monika Bauden Yi Jiang Roland Andersson Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma BMC Cancer Pancreatic ductal adenocarcinoma CLCA1 Calcium-activated chloride channel regulators Survival |
author_facet |
Dingyuan Hu Daniel Ansari Qimin Zhou Agata Sasor Katarzyna Said Hilmersson Monika Bauden Yi Jiang Roland Andersson |
author_sort |
Dingyuan Hu |
title |
Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma |
title_short |
Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma |
title_full |
Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma |
title_fullStr |
Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma |
title_full_unstemmed |
Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma |
title_sort |
calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2018-11-01 |
description |
Abstract Background In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression was inversely correlated with patient survival. The aim of the study was to further validate the prognostic significance of CLCA1 in pancreatic cancer. Methods CLCA1 expression was evaluated with tissue microarrays and immunohistochemistry in 140 patients with pancreatic ductal adenocarcinoma that underwent surgical resection at Skåne University Hospital, Sweden. Kaplan-Meier and Cox proportional hazards modeling were used to explore the association between CLCA1 and clinicopathological factors and survival. Results CLCA1 expression was denoted as positive in 90 tumors (64.3%), with positive staining being limited to the tumor cells. There were no significant association between CLCA1 expression and established clinicopathological parameters. Low CLCA1 expression correlated significantly with shorter disease-free survival (11.9 vs 17.5 months, P = 0.042). Multivariable Cox regression analysis confirmed the results (HR 0.61, 95% CI-0.40-0.92, P = 0.019). Conclusions Low CLCA1 expression is an independent factor of poor disease-free survival in pancreatic cancer. |
topic |
Pancreatic ductal adenocarcinoma CLCA1 Calcium-activated chloride channel regulators Survival |
url |
http://link.springer.com/article/10.1186/s12885-018-5013-2 |
work_keys_str_mv |
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