The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern Malaysians
The present study explored the differences in gastric microbiome between three distinct populations of Southeast Asia. These include the isolated Orang Asli population and modern Malaysians, as well as patients from Myanmar, the least developed country in the region. All 79 subjects recruited in thi...
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doaj-ccb2e6f1db454caca8663915b8bc45602020-11-25T00:25:58ZengMDPI AGMicroorganisms2076-26072019-06-017617410.3390/microorganisms7060174microorganisms7060174The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern MalaysiansEng Guan Chua0Mun Fai Loke1Selva Perumal Gunaletchumy2Han Ming Gan3Kavitha Thevakumar4Chin Yen Tay5Sylvia Young6Than Than Aye7Win Win Maw8Mya Mya Aye9Alex Hwong-Ruey Leow10Ahmad Najib Azmi11Sri Ganesh Kalimuthu12Haji Mohd Akmal Bin Dato Dahlan13Khean Lee Goh14Jamuna Vadivelu15The Marshall Centre for Infectious Diseases Research and Training, University of Western Australia, Perth, WA 6009, AustraliaDepartment of Medical Microbiology, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Medical Microbiology, University of Malaya, Kuala Lumpur 50603, MalaysiaSchool of Science, Monash University Malaysia, Selangor 47500, MalaysiaDepartment of Medical Microbiology, University of Malaya, Kuala Lumpur 50603, MalaysiaThe Marshall Centre for Infectious Diseases Research and Training, University of Western Australia, Perth, WA 6009, AustraliaHarry Perkins Institute of Medical Research, The Centre for Medical Research at the University of Western Australia, Perth, WA 6009, AustraliaDepartment of Gastroenterology, Thingangyun Sanpya General Hospital, Yangon 11071, MyanmarMicrobiology Department, University of Medicine 2, Yangon 11031, MyanmarUniversity of Medical Technology, Mandalay 05071, MyanmarDepartment of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaCliniPath Malaysia Sdn Bhd, Kuala Lumpur 55100, MalaysiaHospital Orang Asli Gombak, Selangor 53100, MalaysiaDepartment of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Medical Microbiology, University of Malaya, Kuala Lumpur 50603, MalaysiaThe present study explored the differences in gastric microbiome between three distinct populations of Southeast Asia. These include the isolated Orang Asli population and modern Malaysians, as well as patients from Myanmar, the least developed country in the region. All 79 subjects recruited in this study had <i>Helicobacter pylori</i> infection. Based on alpha diversity analysis, Orang Asli had the richest and most diverse gastric microbiome, followed by Myanmar and modern Malaysian groups. Beta diversity analysis revealed significant separation of samples between different populations. These observations are likely to be associated with the level of modernization of each population. Our data further suggested increased bacterial species richness and diversity of the gastric microbiome in individuals who were less modernized, particularly in the Orang Asli group, could suppress the growth of <i>H. pylori</i>. In addition, there were significant variations in the gastric microbiome between modern Malaysians with different types of gastric diseases. Notably, <i>Cutibacterium acnes</i> was present at significantly greater abundance level in patients with non-ulcerative dyspepsia than those with peptic-ulcer diagnosis. This suggests that <i>C. acnes</i> may also play a role in gastritis besides <i>H. pylori</i>, which merits further investigation.https://www.mdpi.com/2076-2607/7/6/174<i>Helicobacter pylori</i><i>16S rRNA</i> gene sequencingOrang AsliMyanmarMalaysiangastric diseasebeta diversitymicrobiome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eng Guan Chua Mun Fai Loke Selva Perumal Gunaletchumy Han Ming Gan Kavitha Thevakumar Chin Yen Tay Sylvia Young Than Than Aye Win Win Maw Mya Mya Aye Alex Hwong-Ruey Leow Ahmad Najib Azmi Sri Ganesh Kalimuthu Haji Mohd Akmal Bin Dato Dahlan Khean Lee Goh Jamuna Vadivelu |
spellingShingle |
Eng Guan Chua Mun Fai Loke Selva Perumal Gunaletchumy Han Ming Gan Kavitha Thevakumar Chin Yen Tay Sylvia Young Than Than Aye Win Win Maw Mya Mya Aye Alex Hwong-Ruey Leow Ahmad Najib Azmi Sri Ganesh Kalimuthu Haji Mohd Akmal Bin Dato Dahlan Khean Lee Goh Jamuna Vadivelu The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern Malaysians Microorganisms <i>Helicobacter pylori</i> <i>16S rRNA</i> gene sequencing Orang Asli Myanmar Malaysian gastric disease beta diversity microbiome |
author_facet |
Eng Guan Chua Mun Fai Loke Selva Perumal Gunaletchumy Han Ming Gan Kavitha Thevakumar Chin Yen Tay Sylvia Young Than Than Aye Win Win Maw Mya Mya Aye Alex Hwong-Ruey Leow Ahmad Najib Azmi Sri Ganesh Kalimuthu Haji Mohd Akmal Bin Dato Dahlan Khean Lee Goh Jamuna Vadivelu |
author_sort |
Eng Guan Chua |
title |
The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern Malaysians |
title_short |
The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern Malaysians |
title_full |
The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern Malaysians |
title_fullStr |
The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern Malaysians |
title_full_unstemmed |
The Influence of Modernization and Disease on the Gastric Microbiome of Orang Asli, Myanmars and Modern Malaysians |
title_sort |
influence of modernization and disease on the gastric microbiome of orang asli, myanmars and modern malaysians |
publisher |
MDPI AG |
series |
Microorganisms |
issn |
2076-2607 |
publishDate |
2019-06-01 |
description |
The present study explored the differences in gastric microbiome between three distinct populations of Southeast Asia. These include the isolated Orang Asli population and modern Malaysians, as well as patients from Myanmar, the least developed country in the region. All 79 subjects recruited in this study had <i>Helicobacter pylori</i> infection. Based on alpha diversity analysis, Orang Asli had the richest and most diverse gastric microbiome, followed by Myanmar and modern Malaysian groups. Beta diversity analysis revealed significant separation of samples between different populations. These observations are likely to be associated with the level of modernization of each population. Our data further suggested increased bacterial species richness and diversity of the gastric microbiome in individuals who were less modernized, particularly in the Orang Asli group, could suppress the growth of <i>H. pylori</i>. In addition, there were significant variations in the gastric microbiome between modern Malaysians with different types of gastric diseases. Notably, <i>Cutibacterium acnes</i> was present at significantly greater abundance level in patients with non-ulcerative dyspepsia than those with peptic-ulcer diagnosis. This suggests that <i>C. acnes</i> may also play a role in gastritis besides <i>H. pylori</i>, which merits further investigation. |
topic |
<i>Helicobacter pylori</i> <i>16S rRNA</i> gene sequencing Orang Asli Myanmar Malaysian gastric disease beta diversity microbiome |
url |
https://www.mdpi.com/2076-2607/7/6/174 |
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