The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling
Abstract The efficient induction and long-term persistence of pathogen-specific memory CD8 T cells are pivotal to rapidly curb the reinfection. Recent studies indicated that long-noncoding RNAs expression is highly cell- and stage-specific during T cell development and differentiation, suggesting th...
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doaj-ccb3befdc2754c018ded748254cf1d302021-03-28T11:17:33ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352021-03-016111410.1038/s41392-021-00492-9The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signalingYanyan Zhang0Baohua Li1Qiang Bai2Pengcheng Wang3Gang Wei4Zhirong Li5Li Hu6Qin Tian7Jing Zhou8Qizhao Huang9Zhiming Wang10Shuai Yue11Jialin Wu12Liuqing Yang13Xinyuan Zhou14Lubin Jiang15Ting Ni16Lilin Ye17Yuzhang Wu18Institute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityHuman Phenome Institute, Fudan UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterInstitute of Immunology PLA, Third Military Medical UniversityInstitute Pasteur of Shanghai, Chinese Academy of Sciences (CAS)Human Phenome Institute, Fudan UniversityInstitute of Immunology PLA, Third Military Medical UniversityInstitute of Immunology PLA, Third Military Medical UniversityAbstract The efficient induction and long-term persistence of pathogen-specific memory CD8 T cells are pivotal to rapidly curb the reinfection. Recent studies indicated that long-noncoding RNAs expression is highly cell- and stage-specific during T cell development and differentiation, suggesting their potential roles in T cell programs. However, the key lncRNAs playing crucial roles in memory CD8 T cell establishment remain to be clarified. Through CD8 T cell subsets profiling of lncRNAs, this study found a key lncRNA-Snhg1 with the conserved naivehi-effectorlo-memoryhi expression pattern in CD8 T cells of both mice and human, that can promote memory formation while impeding effector CD8 in acute viral infection. Further, Snhg1 was found interacting with the conserved vesicle trafficking protein Vps13D to promote IL-7Rα membrane location specifically. With the deep mechanism probing, the results show Snhg1-Vps13D regulated IL-7 signaling with its dual effects in memory CD8 generation, which not just because of the sustaining role of STAT5-BCL-2 axis for memory survival, but more through the STAT3-TCF1-Blimp1 axis for transcriptional launch program of memory differentiation. Moreover, we performed further study with finding a similar high-low-high expression pattern of human SNHG1/VPS13D/IL7R/TCF7 in CD8 T cell subsets from PBMC samples of the convalescent COVID-19 patients. The central role of Snhg1-Vps13D-IL-7R-TCF1 axis in memory CD8 establishment makes it a potential target for improving the vaccination effects to control the ongoing pandemic.https://doi.org/10.1038/s41392-021-00492-9 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yanyan Zhang Baohua Li Qiang Bai Pengcheng Wang Gang Wei Zhirong Li Li Hu Qin Tian Jing Zhou Qizhao Huang Zhiming Wang Shuai Yue Jialin Wu Liuqing Yang Xinyuan Zhou Lubin Jiang Ting Ni Lilin Ye Yuzhang Wu |
spellingShingle |
Yanyan Zhang Baohua Li Qiang Bai Pengcheng Wang Gang Wei Zhirong Li Li Hu Qin Tian Jing Zhou Qizhao Huang Zhiming Wang Shuai Yue Jialin Wu Liuqing Yang Xinyuan Zhou Lubin Jiang Ting Ni Lilin Ye Yuzhang Wu The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling Signal Transduction and Targeted Therapy |
author_facet |
Yanyan Zhang Baohua Li Qiang Bai Pengcheng Wang Gang Wei Zhirong Li Li Hu Qin Tian Jing Zhou Qizhao Huang Zhiming Wang Shuai Yue Jialin Wu Liuqing Yang Xinyuan Zhou Lubin Jiang Ting Ni Lilin Ye Yuzhang Wu |
author_sort |
Yanyan Zhang |
title |
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling |
title_short |
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling |
title_full |
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling |
title_fullStr |
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling |
title_full_unstemmed |
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling |
title_sort |
lncrna snhg1-vps13d vesicle trafficking system promotes memory cd8 t cell establishment via regulating the dual effects of il-7 signaling |
publisher |
Nature Publishing Group |
series |
Signal Transduction and Targeted Therapy |
issn |
2059-3635 |
publishDate |
2021-03-01 |
description |
Abstract The efficient induction and long-term persistence of pathogen-specific memory CD8 T cells are pivotal to rapidly curb the reinfection. Recent studies indicated that long-noncoding RNAs expression is highly cell- and stage-specific during T cell development and differentiation, suggesting their potential roles in T cell programs. However, the key lncRNAs playing crucial roles in memory CD8 T cell establishment remain to be clarified. Through CD8 T cell subsets profiling of lncRNAs, this study found a key lncRNA-Snhg1 with the conserved naivehi-effectorlo-memoryhi expression pattern in CD8 T cells of both mice and human, that can promote memory formation while impeding effector CD8 in acute viral infection. Further, Snhg1 was found interacting with the conserved vesicle trafficking protein Vps13D to promote IL-7Rα membrane location specifically. With the deep mechanism probing, the results show Snhg1-Vps13D regulated IL-7 signaling with its dual effects in memory CD8 generation, which not just because of the sustaining role of STAT5-BCL-2 axis for memory survival, but more through the STAT3-TCF1-Blimp1 axis for transcriptional launch program of memory differentiation. Moreover, we performed further study with finding a similar high-low-high expression pattern of human SNHG1/VPS13D/IL7R/TCF7 in CD8 T cell subsets from PBMC samples of the convalescent COVID-19 patients. The central role of Snhg1-Vps13D-IL-7R-TCF1 axis in memory CD8 establishment makes it a potential target for improving the vaccination effects to control the ongoing pandemic. |
url |
https://doi.org/10.1038/s41392-021-00492-9 |
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