Expression of MALAT1 gene in esophageal carcinoma and its relationship with tumor progression

• Main Authors: Jing Liu, Yan Jin
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-01-01
• Series: Journal of Hainan Medical University
• Online Access: http://www.hnykdxxb.com/PDF/201902/11.pdf

Objective: To investigate the expression of MALAT1 gene in esophageal carcinoma and its relationship with tumor progression. Methods: A total of 98 patients with primary esophageal cancer who underwent radical operation for esophageal cancer in our hospital between August 2015 and December 2017 were selected as the research subjects, and the tissue specimens obtained during operation were divided into esophageal cancer tissues and tissues adjacent to carcinoma. The differences in the expression of MALAT1 gene, esophageal cancer proliferation-related genes and esophageal cancer invasion-related genes in different esophageal cancer tissues were compared, and correlation analysis was used to further evaluate the inner link between MALAT1 gene expression in esophageal cancer tissues and tumor condition. Results: MALAT1 mRNA expression in esophageal cancer tissues was higher than that in adjacent tissues; proliferation-related genes FOXA1, MACC1, MAGE-A1, Nucleostemin and ABCE1 mRNA expression were higher than those in adjacent tissues whereas KLF4 mRNA expression was lower than that in adjacent tissues; invasion-related genes PAR-2, PEBP4, UHRF1 and Nestin mRNA expression were higher than those in adjacent tissues whereas TSLC1 mRNA expression was lower than that in adjacent tissues. Pearson test showed that the MALAT1 gene expression in esophageal cancer was directly correlated with the proliferation and invasion activity of cancer cells. Conclusion: The expression of MALAT1 gene abnormally increases in esophageal cancer tissues, and the proliferation and invasion activity of cancer cells increase with the increase of the gene expression.