Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors
Summary: Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by amacrine cells and bipolar cells, the behavio...
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doaj-ccb8eacb0ddb4b22aab4eb82c937cdc62020-11-25T00:31:12ZengElsevierCell Reports2211-12472019-06-01271028712880.e2Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA ReceptorsRong-wei Zhang0Wen-jie Du1David A. Prober2Jiu-lin Du3Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; Corresponding authorInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, ChinaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USAInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, 319 Yue-Yang Road, Shanghai 200031, China; School of Future Technology, University of Chinese Academy of Sciences, 19A Yu-Quan Road, Beijing 100049, China; Corresponding authorSummary: Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by amacrine cells and bipolar cells, the behavior and function of glia in retinal waves remain unclear. Using multiple in vivo methods in larval zebrafish, we found that Müller glial cells (MGCs) display wave-like spontaneous activities, which start at MGC processes within the inner plexiform layer, vertically spread to their somata and endfeet, and horizontally propagate into neighboring MGCs. MGC waves depend on glutamatergic signaling derived from bipolar cells. Moreover, MGCs express both glia-specific glutamate transporters and the AMPA subtype of glutamate receptors. The AMPA receptors mediate MGC calcium activities during retinal waves, whereas the glutamate transporters modulate the occurrence of retinal waves. Thus, MGCs can sense and regulate retinal waves via AMPA receptors and glutamate transporters, respectively. : The behavior and function of glial cells in spontaneous retinal waves remain unclear. Using in vivo calcium imaging and electrophysiological recording in larval zebrafish, Zhang et al. show that Müller glial cells can participate in and modulate retinal waves, respectively, via AMPA receptors and glutamate transporters on their own processes. Keywords: retinal wave, Müller glial cell, glutamate transporter, AMPA receptor, zebrafishhttp://www.sciencedirect.com/science/article/pii/S2211124719306229 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rong-wei Zhang Wen-jie Du David A. Prober Jiu-lin Du |
spellingShingle |
Rong-wei Zhang Wen-jie Du David A. Prober Jiu-lin Du Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors Cell Reports |
author_facet |
Rong-wei Zhang Wen-jie Du David A. Prober Jiu-lin Du |
author_sort |
Rong-wei Zhang |
title |
Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors |
title_short |
Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors |
title_full |
Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors |
title_fullStr |
Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors |
title_full_unstemmed |
Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors |
title_sort |
müller glial cells participate in retinal waves via glutamate transporters and ampa receptors |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2019-06-01 |
description |
Summary: Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by amacrine cells and bipolar cells, the behavior and function of glia in retinal waves remain unclear. Using multiple in vivo methods in larval zebrafish, we found that Müller glial cells (MGCs) display wave-like spontaneous activities, which start at MGC processes within the inner plexiform layer, vertically spread to their somata and endfeet, and horizontally propagate into neighboring MGCs. MGC waves depend on glutamatergic signaling derived from bipolar cells. Moreover, MGCs express both glia-specific glutamate transporters and the AMPA subtype of glutamate receptors. The AMPA receptors mediate MGC calcium activities during retinal waves, whereas the glutamate transporters modulate the occurrence of retinal waves. Thus, MGCs can sense and regulate retinal waves via AMPA receptors and glutamate transporters, respectively. : The behavior and function of glial cells in spontaneous retinal waves remain unclear. Using in vivo calcium imaging and electrophysiological recording in larval zebrafish, Zhang et al. show that Müller glial cells can participate in and modulate retinal waves, respectively, via AMPA receptors and glutamate transporters on their own processes. Keywords: retinal wave, Müller glial cell, glutamate transporter, AMPA receptor, zebrafish |
url |
http://www.sciencedirect.com/science/article/pii/S2211124719306229 |
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