PBK attenuates paclitaxel‐induced autophagic cell death by suppressing p53 in H460 non‐small‐cell lung cancer cells

PBK attenuates paclitaxel‐induced autophagic cell death by suppressing p53 in H460 non‐small‐cell lung cancer cells

PDZ‐binding kinase (PBK) has previously been shown to mediate chemoresistance of cancer cells to anticancer drugs. However, it remains unclear how PBK regulates paclitaxel‐induced cancer cell death. Here, we demonstrate that PBK hinders paclitaxel‐mediated autophagic cell death in H460 non‐small‐cel...

Full description

Bibliographic Details
Main Authors: Jung‐Hwan Park, Sang‐Ah Park, Young‐Ju Lee, Hwan‐Woo Park, Sang‐Muk Oh
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:FEBS Open Bio
Subjects:
Mdm2
non‐small‐cell lung cancer cells
p53
PBK
ubiquitination
Online Access:https://doi.org/10.1002/2211-5463.12855

Similar Items

Similar Items