Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells

Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells

Abstract Background To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells. Methods We evaluated whether L. sakei reduced the severity of collagen-induced arthritis (CIA) and modulated interleukin (IL)-17 and IL-10 level...

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Bibliographic Details
Main Authors: Jooyeon Jhun, Hong Ki Min, Jaeyoon Ryu, Seon-Yeong Lee, Jun-Geol Ryu, Jeong Won Choi, Hyun Sik Na, Seung Yoon Lee, Yunju Jung, Sang-Jun Park, Myeong Soo Park, Bin Kwon, Geun Eog Ji, Mi-La Cho, Sung-Hwan Park
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Translational Medicine
Subjects:
Rheumatoid arthritis
Microbiome
Lactobacillus sakei
T helper 17 cell
Regulatory B cell
Online Access:http://link.springer.com/article/10.1186/s12967-020-02477-8

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