Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway

Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway

Abstract Background We developed a non-viral vector, a combination of HIV-1 Tat peptide modified with histidine and cysteine (mTat) and polyethylenimine, jetPEI (PEI), displaying the high efficiency of plasmid DNA transfection with little toxicity. Since the highest efficiency of INTERFERin (INT), a...

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Bibliographic Details
Main Authors: Hironori Kasai, Kenji Inoue, Kentaro Imamura, Carlo Yuvienco, Jin K. Montclare, Seiichi Yamano
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Nanobiotechnology
Subjects:
Gene delivery
Non-viral vector
Small interfering RNA
Transfection
RNA interference
Online Access:http://link.springer.com/article/10.1186/s12951-019-0444-8

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