Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis

Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis

The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to de...

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Bibliographic Details
Main Authors: Haeja Kessler, Kaiyu Jiang, James N. Jarvis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
juvenile idiopathic arthritis (JIA)
genetics
enhancer
non-coding genome
topically associated domains
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02964/full
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spelling doaj-ccf530345a6441fd8ec63a03d5f2046b2020-11-25T00:56:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-12-01910.3389/fimmu.2018.02964434464Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic ArthritisHaeja Kessler0Kaiyu Jiang1James N. Jarvis2James N. Jarvis3Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United StatesDepartment of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United StatesDepartment of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United StatesGenetics, Genomics, and Bioinformatics Program, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United StatesThe presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to develop a better understanding of the mechanisms driving these gene expression patterns.https://www.frontiersin.org/article/10.3389/fimmu.2018.02964/fulljuvenile idiopathic arthritis (JIA)geneticsenhancernon-coding genometopically associated domains
collection DOAJ
language English
format Article
sources DOAJ
author Haeja Kessler
Kaiyu Jiang
James N. Jarvis
James N. Jarvis
spellingShingle Haeja Kessler
Kaiyu Jiang
James N. Jarvis
James N. Jarvis
Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
Frontiers in Immunology
juvenile idiopathic arthritis (JIA)
genetics
enhancer
non-coding genome
topically associated domains
author_facet Haeja Kessler
Kaiyu Jiang
James N. Jarvis
James N. Jarvis
author_sort Haeja Kessler
title Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_short Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_full Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_fullStr Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_full_unstemmed Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis
title_sort using chromatin architecture to understand the genetics and transcriptomics of juvenile idiopathic arthritis
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2018-12-01
description The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to develop a better understanding of the mechanisms driving these gene expression patterns.
topic juvenile idiopathic arthritis (JIA)
genetics
enhancer
non-coding genome
topically associated domains
url https://www.frontiersin.org/article/10.3389/fimmu.2018.02964/full
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