Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents

Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents

<div align="justify">Some new 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1Htetrazol1-yl) ethyl] amino} azetidin-2-one have been synthesized from Schiff bases of 5-phenyltetrazole. The Schiff bases were obtained by condensation 2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide w...

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Main Authors: P. B. Mohite, V. H. Bhaskar
Format: Article
Language:English
Published: Universidade Federal de Mato Grosso do Sul 2011-05-01
Series:Orbital: The Electronic Journal of Chemistry
Subjects:
tetrazole
azetidinone derivatives
antibacterial activity
antitubercular activity
Online Access:http://orbital.ufms.br/index.php/Chemistry/article/view/185
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spelling doaj-cd06a6aea9674556be6e84568605884f2021-07-07T19:22:33ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282011-05-012434735510.17807/orbital.v2i4.18571Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agentsP. B. MohiteV. H. Bhaskar<div align="justify">Some new 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1Htetrazol1-yl) ethyl] amino} azetidin-2-one have been synthesized from Schiff bases of 5-phenyltetrazole. The Schiff bases were obtained by condensation 2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide with various aromatic aldehydes. Cyclocondensation of Schiff&rsquo;s bases with chloroacetylchloride in the presence of triethylamine results in azetidinone derivatives. The structures of the newly synthesized azatidinones were confirmed by FT-IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds have exhibited significant activity against the bacteria and fungi tested. </div>http://orbital.ufms.br/index.php/Chemistry/article/view/185tetrazoleazetidinone derivativesantibacterial activityantitubercular activity
collection DOAJ
language English
format Article
sources DOAJ
author P. B. Mohite
V. H. Bhaskar
spellingShingle P. B. Mohite
V. H. Bhaskar
Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents
Orbital: The Electronic Journal of Chemistry
tetrazole
azetidinone derivatives
antibacterial activity
antitubercular activity
author_facet P. B. Mohite
V. H. Bhaskar
author_sort P. B. Mohite
title Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents
title_short Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents
title_full Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents
title_fullStr Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents
title_full_unstemmed Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents
title_sort synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents
publisher Universidade Federal de Mato Grosso do Sul
series Orbital: The Electronic Journal of Chemistry
issn 1984-6428
publishDate 2011-05-01
description <div align="justify">Some new 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1Htetrazol1-yl) ethyl] amino} azetidin-2-one have been synthesized from Schiff bases of 5-phenyltetrazole. The Schiff bases were obtained by condensation 2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide with various aromatic aldehydes. Cyclocondensation of Schiff&rsquo;s bases with chloroacetylchloride in the presence of triethylamine results in azetidinone derivatives. The structures of the newly synthesized azatidinones were confirmed by FT-IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds have exhibited significant activity against the bacteria and fungi tested. </div>
topic tetrazole
azetidinone derivatives
antibacterial activity
antitubercular activity
url http://orbital.ufms.br/index.php/Chemistry/article/view/185
work_keys_str_mv AT pbmohite synthesisandbiologicalactivitiesofsome3chloro4substitutedphenyl12oxo25phenyl1htetrazol1ylethylaminoazetidin2oneaspotentialantibacterialagents
AT vhbhaskar synthesisandbiologicalactivitiesofsome3chloro4substitutedphenyl12oxo25phenyl1htetrazol1ylethylaminoazetidin2oneaspotentialantibacterialagents
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