CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin

CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin

Summary: Limited therapeutic options are available for advanced colorectal cancer (CRC). Herein, we report that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, nortopsentin 234 (NORA234), leads to an initial reduction of proliferative and clonogenic potential of CRC sphere cells (C...

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Bibliographic Details
Main Authors: Simone Di Franco, Barbara Parrino, Miriam Gaggianesi, Vincenzo Davide Pantina, Paola Bianca, Annalisa Nicotra, Laura Rosa Mangiapane, Melania Lo Iacono, Gloria Ganduscio, Veronica Veschi, Ornella Roberta Brancato, Antonino Glaviano, Alice Turdo, Irene Pillitteri, Lorenzo Colarossi, Stella Cascioferro, Daniela Carbone, Camilla Pecoraro, Micol Eleonora Fiori, Ruggero De Maria, Matilde Todaro, Isabella Screpanti, Girolamo Cirrincione, Patrizia Diana, Giorgio Stassi
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Cancer
Cell Biology
Drugs
Molecular Physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221006325

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