Genetic Diversity and Distribution of Peromyscus-Borne Hantaviruses in North America
The 1993 outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was associated with Sin Nombre virus, a rodent-borne hantavirus; The virus' primary reservoir is the deer mouse (Peromyscus maniculatus). Hantavirus-infected rodents were identified in various regions of...
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1999-02-01
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doaj-cd2b714393ae424887c2cfdca1c3bcd22020-11-24T21:50:38ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60591999-02-0151758610.3201/eid0501.990109Genetic Diversity and Distribution of Peromyscus-Borne Hantaviruses in North AmericaMartha C. MonroeSergey P. MorzunovAngela M. JohnsonMichael D. BowenHarvey ArtsobTerry YatesC.J. PetersPierre E. RollinThomas G. KsiazekStuart T. NicholThe 1993 outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was associated with Sin Nombre virus, a rodent-borne hantavirus; The virus' primary reservoir is the deer mouse (Peromyscus maniculatus). Hantavirus-infected rodents were identified in various regions of North America. An extensive nucleotide sequence database of an 139 bp fragment amplified from virus M genomic segments was generated. Phylogenetic analysis confirmed that SNV-like hantaviruses are widely distributed in Peromyscus species rodents throughout North America. Classic SNV is the major cause of HPS in North America, but other Peromyscine-borne hantaviruses, e.g., New York and Monongahela viruses, are also associated with HPS cases. Although genetically diverse, SNV-like viruses have slowly coevolved with their rodent hosts. We show that the genetic relationships of hantaviruses in the Americas are complex, most likely as a result of the rapid radiation and speciation of New World sigmodontine rodents and occasional virus-host switching events.https://wwwnc.cdc.gov/eid/article/5/1/99-0109_articleCanadaUnited States |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martha C. Monroe Sergey P. Morzunov Angela M. Johnson Michael D. Bowen Harvey Artsob Terry Yates C.J. Peters Pierre E. Rollin Thomas G. Ksiazek Stuart T. Nichol |
spellingShingle |
Martha C. Monroe Sergey P. Morzunov Angela M. Johnson Michael D. Bowen Harvey Artsob Terry Yates C.J. Peters Pierre E. Rollin Thomas G. Ksiazek Stuart T. Nichol Genetic Diversity and Distribution of Peromyscus-Borne Hantaviruses in North America Emerging Infectious Diseases Canada United States |
author_facet |
Martha C. Monroe Sergey P. Morzunov Angela M. Johnson Michael D. Bowen Harvey Artsob Terry Yates C.J. Peters Pierre E. Rollin Thomas G. Ksiazek Stuart T. Nichol |
author_sort |
Martha C. Monroe |
title |
Genetic Diversity and Distribution of Peromyscus-Borne Hantaviruses in North America |
title_short |
Genetic Diversity and Distribution of Peromyscus-Borne Hantaviruses in North America |
title_full |
Genetic Diversity and Distribution of Peromyscus-Borne Hantaviruses in North America |
title_fullStr |
Genetic Diversity and Distribution of Peromyscus-Borne Hantaviruses in North America |
title_full_unstemmed |
Genetic Diversity and Distribution of Peromyscus-Borne Hantaviruses in North America |
title_sort |
genetic diversity and distribution of peromyscus-borne hantaviruses in north america |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
1999-02-01 |
description |
The 1993 outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was associated with Sin Nombre virus, a rodent-borne hantavirus; The virus' primary reservoir is the deer mouse (Peromyscus maniculatus). Hantavirus-infected rodents were identified in various regions of North America. An extensive nucleotide sequence database of an 139 bp fragment amplified from virus M genomic segments was generated. Phylogenetic analysis confirmed that SNV-like hantaviruses are widely distributed in Peromyscus species rodents throughout North America. Classic SNV is the major cause of HPS in North America, but other Peromyscine-borne hantaviruses, e.g., New York and Monongahela viruses, are also associated with HPS cases. Although genetically diverse, SNV-like viruses have slowly coevolved with their rodent hosts. We show that the genetic relationships of hantaviruses in the Americas are complex, most likely as a result of the rapid radiation and speciation of New World sigmodontine rodents and occasional virus-host switching events. |
topic |
Canada United States |
url |
https://wwwnc.cdc.gov/eid/article/5/1/99-0109_article |
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