Insights into Australian Bat Lyssavirus in Insectivorous Bats of Western Australia
Australian bat lyssavirus (ABLV) is a known causative agent of neurological disease in bats, humans and horses. It has been isolated from four species of pteropid bats and a single microbat species (Saccolaimus flaviventris). To date, ABLV surveillance has primarily been passive, with active surveil...
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doaj-cd2c1f896ffe49cfb069ab6ed3eefd202020-11-25T00:33:48ZengMDPI AGTropical Medicine and Infectious Disease2414-63662019-03-01414610.3390/tropicalmed4010046tropicalmed4010046Insights into Australian Bat Lyssavirus in Insectivorous Bats of Western AustraliaDiana Prada0Victoria Boyd1Michelle Baker2Bethany Jackson3Mark O’Dea4School of Veterinary Medicine, Murdoch University, Perth, WA 6150, AustraliaAustralian Animal Health Laboratory, CSIRO, Geelong, VIC 3220, AustraliaAustralian Animal Health Laboratory, CSIRO, Geelong, VIC 3220, AustraliaSchool of Veterinary Medicine, Murdoch University, Perth, WA 6150, AustraliaSchool of Veterinary Medicine, Murdoch University, Perth, WA 6150, AustraliaAustralian bat lyssavirus (ABLV) is a known causative agent of neurological disease in bats, humans and horses. It has been isolated from four species of pteropid bats and a single microbat species (Saccolaimus flaviventris). To date, ABLV surveillance has primarily been passive, with active surveillance concentrating on eastern and northern Australian bat populations. As a result, there is scant regional ABLV information for large areas of the country. To better inform the local public health risks associated with human-bat interactions, this study describes the lyssavirus prevalence in microbat communities in the South West Botanical Province of Western Australia. We used targeted real-time PCR assays to detect viral RNA shedding in 839 oral swabs representing 12 species of microbats, which were sampled over two consecutive summers spanning 2016–2018. Additionally, we tested 649 serum samples via Luminex® assay for reactivity to lyssavirus antigens. Active lyssavirus infection was not detected in any of the samples. Lyssavirus antibodies were detected in 19 individuals across six species, with a crude prevalence of 2.9% (95% CI: 1.8–4.5%) over the two years. In addition, we present the first records of lyssavirus exposure in two Nyctophilus species, and Falsistrellus mackenziei.http://www.mdpi.com/2414-6366/4/1/46Australian bat lyssavirusmicrobatsWestern AustraliaserologyLuminexreal-time PCR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diana Prada Victoria Boyd Michelle Baker Bethany Jackson Mark O’Dea |
spellingShingle |
Diana Prada Victoria Boyd Michelle Baker Bethany Jackson Mark O’Dea Insights into Australian Bat Lyssavirus in Insectivorous Bats of Western Australia Tropical Medicine and Infectious Disease Australian bat lyssavirus microbats Western Australia serology Luminex real-time PCR |
author_facet |
Diana Prada Victoria Boyd Michelle Baker Bethany Jackson Mark O’Dea |
author_sort |
Diana Prada |
title |
Insights into Australian Bat Lyssavirus in Insectivorous Bats of Western Australia |
title_short |
Insights into Australian Bat Lyssavirus in Insectivorous Bats of Western Australia |
title_full |
Insights into Australian Bat Lyssavirus in Insectivorous Bats of Western Australia |
title_fullStr |
Insights into Australian Bat Lyssavirus in Insectivorous Bats of Western Australia |
title_full_unstemmed |
Insights into Australian Bat Lyssavirus in Insectivorous Bats of Western Australia |
title_sort |
insights into australian bat lyssavirus in insectivorous bats of western australia |
publisher |
MDPI AG |
series |
Tropical Medicine and Infectious Disease |
issn |
2414-6366 |
publishDate |
2019-03-01 |
description |
Australian bat lyssavirus (ABLV) is a known causative agent of neurological disease in bats, humans and horses. It has been isolated from four species of pteropid bats and a single microbat species (Saccolaimus flaviventris). To date, ABLV surveillance has primarily been passive, with active surveillance concentrating on eastern and northern Australian bat populations. As a result, there is scant regional ABLV information for large areas of the country. To better inform the local public health risks associated with human-bat interactions, this study describes the lyssavirus prevalence in microbat communities in the South West Botanical Province of Western Australia. We used targeted real-time PCR assays to detect viral RNA shedding in 839 oral swabs representing 12 species of microbats, which were sampled over two consecutive summers spanning 2016–2018. Additionally, we tested 649 serum samples via Luminex® assay for reactivity to lyssavirus antigens. Active lyssavirus infection was not detected in any of the samples. Lyssavirus antibodies were detected in 19 individuals across six species, with a crude prevalence of 2.9% (95% CI: 1.8–4.5%) over the two years. In addition, we present the first records of lyssavirus exposure in two Nyctophilus species, and Falsistrellus mackenziei. |
topic |
Australian bat lyssavirus microbats Western Australia serology Luminex real-time PCR |
url |
http://www.mdpi.com/2414-6366/4/1/46 |
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