Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction?
Introduction. Cognitive deficits are commonly reported by patients with major depressive disorder (MDD). Duloxetine, a dual serotonin/noradrenaline reuptake inhibitor, may improve cognitive deficits in MDD. It is unclear if cognitive improvements occur independently of antidepressant effects with st...
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doaj-cd400d6804e245f5b27ffcfb3effb2ba2020-11-24T20:43:29ZengHindawi LimitedDepression Research and Treatment2090-13212090-133X2014-01-01201410.1155/2014/627863627863Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction?Tracy L. Greer0Prabha Sunderajan1Bruce D. Grannemann2Benji T. Kurian3Madhukar H. Trivedi4Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9119, USADepartment of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9119, USADepartment of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9119, USADepartment of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9119, USADepartment of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9119, USAIntroduction. Cognitive deficits are commonly reported by patients with major depressive disorder (MDD). Duloxetine, a dual serotonin/noradrenaline reuptake inhibitor, may improve cognitive deficits in MDD. It is unclear if cognitive improvements occur independently of antidepressant effects with standard antidepressant medications. Methods. Thirty participants with MDD who endorsed cognitive deficits at screening received 12-week duloxetine treatment. Twenty-one participants completed treatment and baseline and posttreatment cognitive testing. The Cambridge Neuropsychological Test Automated Battery was used to assess the following cognitive domains: attention, visual memory, executive function/set shifting and working memory, executive function/spatial planning, decision making and response control, and verbal learning and memory. Results. Completers showed significant cognitive improvements across several domains on tasks assessing psychomotor function and mental processing speed, with additional improvements in visual and verbal learning and memory, and affective decision making and response control. Overall significance tests for executive function tasks were also significant, although individual tasks were not, perhaps due to the small sample size. Most notably, cognitive improvements were observed independently of symptom reduction on all domains except verbal learning and memory. Conclusions. Patients reporting baseline cognitive deficits achieved cognitive improvements with duloxetine treatment, most of which were independent of symptomatic improvement. This trial is registered with NCT00933439.http://dx.doi.org/10.1155/2014/627863 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tracy L. Greer Prabha Sunderajan Bruce D. Grannemann Benji T. Kurian Madhukar H. Trivedi |
spellingShingle |
Tracy L. Greer Prabha Sunderajan Bruce D. Grannemann Benji T. Kurian Madhukar H. Trivedi Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction? Depression Research and Treatment |
author_facet |
Tracy L. Greer Prabha Sunderajan Bruce D. Grannemann Benji T. Kurian Madhukar H. Trivedi |
author_sort |
Tracy L. Greer |
title |
Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction? |
title_short |
Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction? |
title_full |
Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction? |
title_fullStr |
Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction? |
title_full_unstemmed |
Does Duloxetine Improve Cognitive Function Independently of Its Antidepressant Effect in Patients with Major Depressive Disorder and Subjective Reports of Cognitive Dysfunction? |
title_sort |
does duloxetine improve cognitive function independently of its antidepressant effect in patients with major depressive disorder and subjective reports of cognitive dysfunction? |
publisher |
Hindawi Limited |
series |
Depression Research and Treatment |
issn |
2090-1321 2090-133X |
publishDate |
2014-01-01 |
description |
Introduction. Cognitive deficits are commonly reported by patients with major depressive disorder (MDD). Duloxetine, a dual serotonin/noradrenaline reuptake inhibitor, may improve cognitive deficits in MDD. It is unclear if cognitive improvements occur independently of antidepressant effects with standard antidepressant medications. Methods. Thirty participants with MDD who endorsed cognitive deficits at screening received 12-week duloxetine treatment. Twenty-one participants completed treatment and baseline and posttreatment cognitive testing. The Cambridge Neuropsychological Test Automated Battery was used to assess the following cognitive domains: attention, visual memory, executive function/set shifting and working memory, executive function/spatial planning, decision making and response control, and verbal learning and memory. Results. Completers showed significant cognitive improvements across several domains on tasks assessing psychomotor function and mental processing speed, with additional improvements in visual and verbal learning and memory, and affective decision making and response control. Overall significance tests for executive function tasks were also significant, although individual tasks were not, perhaps due to the small sample size. Most notably, cognitive improvements were observed independently of symptom reduction on all domains except verbal learning and memory. Conclusions. Patients reporting baseline cognitive deficits achieved cognitive improvements with duloxetine treatment, most of which were independent of symptomatic improvement. This trial is registered with
NCT00933439. |
url |
http://dx.doi.org/10.1155/2014/627863 |
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