ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

High-grade serous ovarian cancers (HGSOCs) have defects in homologous recombination despite a lack of BRCA1/2 mutations. Here, the authors show that ZC3H18 positively regulates BRCA1 transcription and its loss causes BRCA1 promoter methylation and increased HR deficiency in HGSOCs.

Bibliographic Details
Main Authors:	Arun Kanakkanthara, Catherine J. Huntoon, Xiaonan Hou, Minzhi Zhang, Ethan P. Heinzen, Daniel R. O’Brien, Ann L. Oberg, S. John Weroha, Scott H. Kaufmann, Larry M. Karnitz
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12610-x

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spelling	doaj-cd553ee268364657964406f6c999755e2021-05-11T12:40:27ZengNature Publishing GroupNature Communications2041-17232019-10-0110111510.1038/s41467-019-12610-xZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancerArun Kanakkanthara0Catherine J. Huntoon1Xiaonan Hou2Minzhi Zhang3Ethan P. Heinzen4Daniel R. O’Brien5Ann L. Oberg6S. John Weroha7Scott H. Kaufmann8Larry M. Karnitz9Division of Oncology Research, Mayo ClinicDivision of Oncology Research, Mayo ClinicDivision of Medical Oncology, Mayo ClinicDivision of Medical Oncology, Mayo ClinicDivision of Biomedical Statistics and Informatics, Mayo ClinicDivision of Biomedical Statistics and Informatics, Mayo ClinicDivision of Biomedical Statistics and Informatics, Mayo ClinicDivision of Medical Oncology, Mayo ClinicDivision of Oncology Research, Mayo ClinicDivision of Oncology Research, Mayo ClinicHigh-grade serous ovarian cancers (HGSOCs) have defects in homologous recombination despite a lack of BRCA1/2 mutations. Here, the authors show that ZC3H18 positively regulates BRCA1 transcription and its loss causes BRCA1 promoter methylation and increased HR deficiency in HGSOCs.https://doi.org/10.1038/s41467-019-12610-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Arun Kanakkanthara Catherine J. Huntoon Xiaonan Hou Minzhi Zhang Ethan P. Heinzen Daniel R. O’Brien Ann L. Oberg S. John Weroha Scott H. Kaufmann Larry M. Karnitz
spellingShingle	Arun Kanakkanthara Catherine J. Huntoon Xiaonan Hou Minzhi Zhang Ethan P. Heinzen Daniel R. O’Brien Ann L. Oberg S. John Weroha Scott H. Kaufmann Larry M. Karnitz ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer Nature Communications
author_facet	Arun Kanakkanthara Catherine J. Huntoon Xiaonan Hou Minzhi Zhang Ethan P. Heinzen Daniel R. O’Brien Ann L. Oberg S. John Weroha Scott H. Kaufmann Larry M. Karnitz
author_sort	Arun Kanakkanthara
title	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_short	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_full	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_fullStr	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_full_unstemmed	ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer
title_sort	zc3h18 specifically binds and activates the brca1 promoter to facilitate homologous recombination in ovarian cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-10-01
description	High-grade serous ovarian cancers (HGSOCs) have defects in homologous recombination despite a lack of BRCA1/2 mutations. Here, the authors show that ZC3H18 positively regulates BRCA1 transcription and its loss causes BRCA1 promoter methylation and increased HR deficiency in HGSOCs.
url	https://doi.org/10.1038/s41467-019-12610-x
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ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

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