Mediterranean diet, stress resilience, and aging in nonhuman primates
Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-11-01
|
Series: | Neurobiology of Stress |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289520300448 |
id |
doaj-cd55cb769e37403e95ab5ff3949d4bea |
---|---|
record_format |
Article |
spelling |
doaj-cd55cb769e37403e95ab5ff3949d4bea2021-01-02T05:12:48ZengElsevierNeurobiology of Stress2352-28952020-11-0113100254Mediterranean diet, stress resilience, and aging in nonhuman primatesCarol A. Shively0Susan E. Appt1Haiying Chen2Stephen M. Day3Brett M. Frye4Hossam A. Shaltout5Marnie G. Silverstein-Metzler6Noah Snyder-Mackler7Beth Uberseder8Mara Z. Vitolins9Thomas C. Register10Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, USA; Corresponding author. Department of Pathology/Comparative Medicine Wake Forest School of Medicine Medical Center Blvd Winston-Salem, NC, 27157-1040, USA.Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, USADepartment of Biostatistics and Data Science, Wake Forest School of Medicine, USADepartment of Internal Medicine/Gerontology and Geriatric Medicine, Wake Forest School of Medicine, USADepartment of Pathology/Comparative Medicine, Wake Forest School of Medicine, USADepartment of Obstetrics and Gynecology, Wake Forest School of Medicine, USADepartment of Pathology/Comparative Medicine, Wake Forest School of Medicine, USASchool of Life Sciences, Center for Evolution and Medicine, Arizona State University, USADepartment of Pathology/Comparative Medicine, Wake Forest School of Medicine, USADepartment of Epidemiology & Prevention, Wake Forest School of Medicine, USADepartment of Pathology/Comparative Medicine, Wake Forest School of Medicine, USAPersistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the effects of stress. However, long-term studies of diet effects on stress reactive systems are not available, and controlled randomized clinical trials are difficult and costly. Here we report the outcomes of a controlled, randomized preclinical trial of the effects of long-term consumption (31 months, ~ equivalent to 9 human years) of Western versus Mediterranean - like diets on behavioral and physiological responses to acute (brief social separation) and chronic (social subordination) psychosocial stress in 38 adult, socially-housed, female cynomolgus macaques. Compared to animals fed a Western diet, those fed the Mediterranean diet exhibited enhanced stress resilience as indicated by lower sympathetic activity, brisker and more overt heart rate responses to acute stress, more rapid recovery, and lower cortisol responses to acute psychological stress and adrenocorticotropin (ACTH) challenge. Furthermore, age-related increases in sympathetic activity and cortisol responses to stress were delayed by the Mediterranean diet. Population level diet modification in humans has been shown to be feasible. Our findings suggest that population-wide adoption of a Mediterranean-like diet pattern may provide a cost-effective intervention on psychological stress and promote healthy aging with the potential for widespread efficacy.http://www.sciencedirect.com/science/article/pii/S2352289520300448Mediterranean dietStress resilienceHypothalamic-pituitary-adrenalAutonomic nervous systemAgingNonhuman primates |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carol A. Shively Susan E. Appt Haiying Chen Stephen M. Day Brett M. Frye Hossam A. Shaltout Marnie G. Silverstein-Metzler Noah Snyder-Mackler Beth Uberseder Mara Z. Vitolins Thomas C. Register |
spellingShingle |
Carol A. Shively Susan E. Appt Haiying Chen Stephen M. Day Brett M. Frye Hossam A. Shaltout Marnie G. Silverstein-Metzler Noah Snyder-Mackler Beth Uberseder Mara Z. Vitolins Thomas C. Register Mediterranean diet, stress resilience, and aging in nonhuman primates Neurobiology of Stress Mediterranean diet Stress resilience Hypothalamic-pituitary-adrenal Autonomic nervous system Aging Nonhuman primates |
author_facet |
Carol A. Shively Susan E. Appt Haiying Chen Stephen M. Day Brett M. Frye Hossam A. Shaltout Marnie G. Silverstein-Metzler Noah Snyder-Mackler Beth Uberseder Mara Z. Vitolins Thomas C. Register |
author_sort |
Carol A. Shively |
title |
Mediterranean diet, stress resilience, and aging in nonhuman primates |
title_short |
Mediterranean diet, stress resilience, and aging in nonhuman primates |
title_full |
Mediterranean diet, stress resilience, and aging in nonhuman primates |
title_fullStr |
Mediterranean diet, stress resilience, and aging in nonhuman primates |
title_full_unstemmed |
Mediterranean diet, stress resilience, and aging in nonhuman primates |
title_sort |
mediterranean diet, stress resilience, and aging in nonhuman primates |
publisher |
Elsevier |
series |
Neurobiology of Stress |
issn |
2352-2895 |
publishDate |
2020-11-01 |
description |
Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the effects of stress. However, long-term studies of diet effects on stress reactive systems are not available, and controlled randomized clinical trials are difficult and costly. Here we report the outcomes of a controlled, randomized preclinical trial of the effects of long-term consumption (31 months, ~ equivalent to 9 human years) of Western versus Mediterranean - like diets on behavioral and physiological responses to acute (brief social separation) and chronic (social subordination) psychosocial stress in 38 adult, socially-housed, female cynomolgus macaques. Compared to animals fed a Western diet, those fed the Mediterranean diet exhibited enhanced stress resilience as indicated by lower sympathetic activity, brisker and more overt heart rate responses to acute stress, more rapid recovery, and lower cortisol responses to acute psychological stress and adrenocorticotropin (ACTH) challenge. Furthermore, age-related increases in sympathetic activity and cortisol responses to stress were delayed by the Mediterranean diet. Population level diet modification in humans has been shown to be feasible. Our findings suggest that population-wide adoption of a Mediterranean-like diet pattern may provide a cost-effective intervention on psychological stress and promote healthy aging with the potential for widespread efficacy. |
topic |
Mediterranean diet Stress resilience Hypothalamic-pituitary-adrenal Autonomic nervous system Aging Nonhuman primates |
url |
http://www.sciencedirect.com/science/article/pii/S2352289520300448 |
work_keys_str_mv |
AT carolashively mediterraneandietstressresilienceandaginginnonhumanprimates AT susaneappt mediterraneandietstressresilienceandaginginnonhumanprimates AT haiyingchen mediterraneandietstressresilienceandaginginnonhumanprimates AT stephenmday mediterraneandietstressresilienceandaginginnonhumanprimates AT brettmfrye mediterraneandietstressresilienceandaginginnonhumanprimates AT hossamashaltout mediterraneandietstressresilienceandaginginnonhumanprimates AT marniegsilversteinmetzler mediterraneandietstressresilienceandaginginnonhumanprimates AT noahsnydermackler mediterraneandietstressresilienceandaginginnonhumanprimates AT bethuberseder mediterraneandietstressresilienceandaginginnonhumanprimates AT marazvitolins mediterraneandietstressresilienceandaginginnonhumanprimates AT thomascregister mediterraneandietstressresilienceandaginginnonhumanprimates |
_version_ |
1724359182220525568 |