Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine
The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million people will die from infections with drug resistant pathogens if no efficient countermeasures are implemented. Evolutio...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-08-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01938/full |
id |
doaj-cd55fc1741eb43a18ded237f955a87e8 |
---|---|
record_format |
Article |
spelling |
doaj-cd55fc1741eb43a18ded237f955a87e82020-11-25T03:51:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01938568485Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision MedicineMatthias Merker0Matthias Merker1Matthias Merker2Leif Tueffers3Leif Tueffers4Marie Vallier5Marie Vallier6Espen E. Groth7Espen E. Groth8Espen E. Groth9Lindsay Sonnenkalb10Daniel Unterweger11Daniel Unterweger12John F. Baines13John F. Baines14Stefan Niemann15Stefan Niemann16Stefan Niemann17Hinrich Schulenburg18Hinrich Schulenburg19Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Hamburg, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanyEvolutionary Ecology and Genetics, Zoological Institute, Christian-Albrechts-Universität, Kiel, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanySection of Evolutionary Medicine, Institute for Experimental Medicine, Kiel University and Max Planck Institute for Evolutionary Biology, Plön, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanyEvolutionary Ecology and Genetics, Zoological Institute, Christian-Albrechts-Universität, Kiel, GermanyDepartment of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, GermanyMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanySection of Evolutionary Medicine, Institute for Experimental Medicine, Kiel University and Max Planck Institute for Evolutionary Biology, Plön, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanySection of Evolutionary Medicine, Institute for Experimental Medicine, Kiel University and Max Planck Institute for Evolutionary Biology, Plön, GermanyMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, GermanyGerman Center for Infection Research (DZIF), Partner Site Borstel-Hamburg-Lübeck-Riems, Hamburg, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanyCluster of Excellence Precision Medicine in Chronic Inflammation, Kiel, GermanyEvolutionary Ecology and Genetics, Zoological Institute, Christian-Albrechts-Universität, Kiel, GermanyThe rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million people will die from infections with drug resistant pathogens if no efficient countermeasures are implemented. Evolution of pathogens lies at the core of this crisis, which enables rapid adaptation to the selective pressures imposed by antimicrobial usage in both medical treatment and agriculture, consequently promoting the spread of resistance genes or alleles in bacterial populations. Approaches developed in the field of Evolutionary Medicine attempt to exploit evolutionary insight into these adaptive processes, with the aim to improve diagnostics and the sustainability of antimicrobial therapy. Here, we review the concept of evolutionary trade-offs in the development of AMR as well as new therapeutic approaches and their impact on host-microbiome-pathogen interactions. We further discuss the possible translation of evolution-informed treatments into clinical practice, considering both the rapid cure of the individual patients and the prevention of AMR.https://www.frontiersin.org/article/10.3389/fimmu.2020.01938/fullAMRdrug resistanceevolutionprecision medicineevolutionary medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthias Merker Matthias Merker Matthias Merker Leif Tueffers Leif Tueffers Marie Vallier Marie Vallier Espen E. Groth Espen E. Groth Espen E. Groth Lindsay Sonnenkalb Daniel Unterweger Daniel Unterweger John F. Baines John F. Baines Stefan Niemann Stefan Niemann Stefan Niemann Hinrich Schulenburg Hinrich Schulenburg |
spellingShingle |
Matthias Merker Matthias Merker Matthias Merker Leif Tueffers Leif Tueffers Marie Vallier Marie Vallier Espen E. Groth Espen E. Groth Espen E. Groth Lindsay Sonnenkalb Daniel Unterweger Daniel Unterweger John F. Baines John F. Baines Stefan Niemann Stefan Niemann Stefan Niemann Hinrich Schulenburg Hinrich Schulenburg Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine Frontiers in Immunology AMR drug resistance evolution precision medicine evolutionary medicine |
author_facet |
Matthias Merker Matthias Merker Matthias Merker Leif Tueffers Leif Tueffers Marie Vallier Marie Vallier Espen E. Groth Espen E. Groth Espen E. Groth Lindsay Sonnenkalb Daniel Unterweger Daniel Unterweger John F. Baines John F. Baines Stefan Niemann Stefan Niemann Stefan Niemann Hinrich Schulenburg Hinrich Schulenburg |
author_sort |
Matthias Merker |
title |
Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine |
title_short |
Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine |
title_full |
Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine |
title_fullStr |
Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine |
title_full_unstemmed |
Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine |
title_sort |
evolutionary approaches to combat antibiotic resistance: opportunities and challenges for precision medicine |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-08-01 |
description |
The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million people will die from infections with drug resistant pathogens if no efficient countermeasures are implemented. Evolution of pathogens lies at the core of this crisis, which enables rapid adaptation to the selective pressures imposed by antimicrobial usage in both medical treatment and agriculture, consequently promoting the spread of resistance genes or alleles in bacterial populations. Approaches developed in the field of Evolutionary Medicine attempt to exploit evolutionary insight into these adaptive processes, with the aim to improve diagnostics and the sustainability of antimicrobial therapy. Here, we review the concept of evolutionary trade-offs in the development of AMR as well as new therapeutic approaches and their impact on host-microbiome-pathogen interactions. We further discuss the possible translation of evolution-informed treatments into clinical practice, considering both the rapid cure of the individual patients and the prevention of AMR. |
topic |
AMR drug resistance evolution precision medicine evolutionary medicine |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.01938/full |
work_keys_str_mv |
AT matthiasmerker evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT matthiasmerker evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT matthiasmerker evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT leiftueffers evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT leiftueffers evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT marievallier evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT marievallier evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT espenegroth evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT espenegroth evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT espenegroth evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT lindsaysonnenkalb evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT danielunterweger evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT danielunterweger evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT johnfbaines evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT johnfbaines evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT stefanniemann evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT stefanniemann evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT stefanniemann evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT hinrichschulenburg evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine AT hinrichschulenburg evolutionaryapproachestocombatantibioticresistanceopportunitiesandchallengesforprecisionmedicine |
_version_ |
1724486884146544640 |