Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain

Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain

Show other versions (1)

Nicotine, the addictive component of cigarette smoke has profound effects on the brain. Activation of its receptors by nicotine has complex consequences for network activity throughout the brain, potentially contributing to the addictive property of the drug. Nicotinic receptors have been implicated...

Full description

Bibliographic Details
Main Authors: Geeta Sharma, Sukumar Vijayaraghavan
Format: Article
Language:English
Published: SAGE Publishing 2008-01-01
Series:Substance Abuse: Research and Treatment
Online Access:https://doi.org/10.1177/117822180800100005
id doaj-cd5601c96a914394a9c9911808a6d9b8
record_format Article
spelling doaj-cd5601c96a914394a9c9911808a6d9b82021-04-02T10:52:01ZengSAGE PublishingSubstance Abuse: Research and Treatment1178-22182008-01-01110.1177/117822180800100005Nicotinic Receptors: Role in Addiction and Other Disorders of the BrainGeeta Sharma0Sukumar Vijayaraghavan1Department of Physiology and Biophysics and the Neuroscience Program, University of Colorado, Denver, School of Medicine Aurora CO 80045.Department of Physiology and Biophysics and the Neuroscience Program, University of Colorado, Denver, School of Medicine Aurora CO 80045.Nicotine, the addictive component of cigarette smoke has profound effects on the brain. Activation of its receptors by nicotine has complex consequences for network activity throughout the brain, potentially contributing to the addictive property of the drug. Nicotinic receptors have been implicated in psychiatric illnesses like schizophrenia and are also neuroprotective, potentially beneficial for neurodegenerative diseases. These effects of nicotine serve to emphasize the multifarious roles the drug, acting through multiple nicotinic acetylcholine receptor subtypes. The findings also remind us of the complexity of signaling mechanisms and stress the risks of unintended consequences of drugs designed to combat nicotine addiction.https://doi.org/10.1177/117822180800100005
collection DOAJ
language English
format Article
sources DOAJ
author Geeta Sharma
Sukumar Vijayaraghavan
spellingShingle Geeta Sharma
Sukumar Vijayaraghavan
Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain
Substance Abuse: Research and Treatment
author_facet Geeta Sharma
Sukumar Vijayaraghavan
author_sort Geeta Sharma
title Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain
title_short Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain
title_full Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain
title_fullStr Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain
title_full_unstemmed Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain
title_sort nicotinic receptors: role in addiction and other disorders of the brain
publisher SAGE Publishing
series Substance Abuse: Research and Treatment
issn 1178-2218
publishDate 2008-01-01
description Nicotine, the addictive component of cigarette smoke has profound effects on the brain. Activation of its receptors by nicotine has complex consequences for network activity throughout the brain, potentially contributing to the addictive property of the drug. Nicotinic receptors have been implicated in psychiatric illnesses like schizophrenia and are also neuroprotective, potentially beneficial for neurodegenerative diseases. These effects of nicotine serve to emphasize the multifarious roles the drug, acting through multiple nicotinic acetylcholine receptor subtypes. The findings also remind us of the complexity of signaling mechanisms and stress the risks of unintended consequences of drugs designed to combat nicotine addiction.
url https://doi.org/10.1177/117822180800100005
work_keys_str_mv AT geetasharma nicotinicreceptorsroleinaddictionandotherdisordersofthebrain
AT sukumarvijayaraghavan nicotinicreceptorsroleinaddictionandotherdisordersofthebrain
_version_ 1724166601700278272

Similar Items