The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trials
Abstract Background The effectiveness of creatine in treating Parkinson’s disease (PD) has not been conclusively determined. Therefore, we performed a meta-analysis to address this issue. Methods The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE, and other databases were searched, a...
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doaj-cd5a030e4eb44cf49f4558b85e3331652020-11-24T21:18:59ZengBMCBMC Neurology1471-23772017-06-011711910.1186/s12883-017-0885-3The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trialsJia-Jie Mo0Lin-Ying Liu1Wei-Bin Peng2Jie Rao3Zhou Liu4Li-Li Cui5Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical UniversityDepartment of Neurology, Chenzhou No. 1 People’s HospitalGraduate School, Guangzhou Medical UniversityDepartment of Pathology, People’s Hospital of Wuhan UniversityGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical UniversityGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical UniversityAbstract Background The effectiveness of creatine in treating Parkinson’s disease (PD) has not been conclusively determined. Therefore, we performed a meta-analysis to address this issue. Methods The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE, and other databases were searched, and outcomes measured by the Total Unified Parkinson’s Disease Rating Scale (UPDRS) and the Schwab & England Scale were analyzed. Results Five randomized controlled trials (RCTs) were selected, and 1339 participants were included in the analysis. There were no significant differences between the control and treatment groups in the total, mental, activities of daily living (ADL), or motor UPDRS scores, but an improvement in Schwab & England Scale scores was observed. Conclusions Creatine has no observed benefit in PD patients, although more correlated studies are still needed.http://link.springer.com/article/10.1186/s12883-017-0885-3CreatineMeta-analysisMitochondrial dysfunctionParkinson’s disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jia-Jie Mo Lin-Ying Liu Wei-Bin Peng Jie Rao Zhou Liu Li-Li Cui |
spellingShingle |
Jia-Jie Mo Lin-Ying Liu Wei-Bin Peng Jie Rao Zhou Liu Li-Li Cui The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trials BMC Neurology Creatine Meta-analysis Mitochondrial dysfunction Parkinson’s disease |
author_facet |
Jia-Jie Mo Lin-Ying Liu Wei-Bin Peng Jie Rao Zhou Liu Li-Li Cui |
author_sort |
Jia-Jie Mo |
title |
The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trials |
title_short |
The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trials |
title_full |
The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trials |
title_fullStr |
The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trials |
title_full_unstemmed |
The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trials |
title_sort |
effectiveness of creatine treatment for parkinson’s disease: an updated meta-analysis of randomized controlled trials |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2017-06-01 |
description |
Abstract Background The effectiveness of creatine in treating Parkinson’s disease (PD) has not been conclusively determined. Therefore, we performed a meta-analysis to address this issue. Methods The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE, and other databases were searched, and outcomes measured by the Total Unified Parkinson’s Disease Rating Scale (UPDRS) and the Schwab & England Scale were analyzed. Results Five randomized controlled trials (RCTs) were selected, and 1339 participants were included in the analysis. There were no significant differences between the control and treatment groups in the total, mental, activities of daily living (ADL), or motor UPDRS scores, but an improvement in Schwab & England Scale scores was observed. Conclusions Creatine has no observed benefit in PD patients, although more correlated studies are still needed. |
topic |
Creatine Meta-analysis Mitochondrial dysfunction Parkinson’s disease |
url |
http://link.springer.com/article/10.1186/s12883-017-0885-3 |
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