The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling
Heart disease remains the single largest cause of death in developed countries, and novel therapeutic interventions are desperately needed to alleviate this growing burden. The cardiac lymphatic system is the long-overlooked counterpart of the coronary blood vasculature, but its important roles in h...
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MDPI AG
2021-02-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/8/2/21 |
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doaj-cd5c0213a2b14ea3b63a91f1771a67212021-02-20T00:02:13ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-02-018212110.3390/jcdd8020021The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease ModelingXidi Feng0Stanislao Travisano1Caroline A. Pearson2Ching-Ling Lien3Michael R. M. Harrison4The Saban Research Institute of Children’s Hospital Los Angeles, Los Angeles, CA 90027, USAThe Saban Research Institute of Children’s Hospital Los Angeles, Los Angeles, CA 90027, USALaboratory of Neurogenetics and Development, Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10021, USAThe Saban Research Institute of Children’s Hospital Los Angeles, Los Angeles, CA 90027, USACardiovascular Research Institute, Weill Cornell Medical College, New York, NY 10021, USAHeart disease remains the single largest cause of death in developed countries, and novel therapeutic interventions are desperately needed to alleviate this growing burden. The cardiac lymphatic system is the long-overlooked counterpart of the coronary blood vasculature, but its important roles in homeostasis and disease are becoming increasingly apparent. Recently, the cardiac lymphatic vasculature in zebrafish has been described and its role in supporting the potent regenerative response of zebrafish heart tissue investigated. In this review, we discuss these findings in the wider context of lymphatic development, evolution and the promise of this system to open new therapeutic avenues to treat myocardial infarction and other cardiopathologies.https://www.mdpi.com/2308-3425/8/2/21cardiac lymphatic vesselszebrafishheartdevelopmentregeneration |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xidi Feng Stanislao Travisano Caroline A. Pearson Ching-Ling Lien Michael R. M. Harrison |
| spellingShingle |
Xidi Feng Stanislao Travisano Caroline A. Pearson Ching-Ling Lien Michael R. M. Harrison The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling Journal of Cardiovascular Development and Disease cardiac lymphatic vessels zebrafish heart development regeneration |
| author_facet |
Xidi Feng Stanislao Travisano Caroline A. Pearson Ching-Ling Lien Michael R. M. Harrison |
| author_sort |
Xidi Feng |
| title |
The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling |
| title_short |
The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling |
| title_full |
The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling |
| title_fullStr |
The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling |
| title_full_unstemmed |
The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling |
| title_sort |
lymphatic system in zebrafish heart development, regeneration and disease modeling |
| publisher |
MDPI AG |
| series |
Journal of Cardiovascular Development and Disease |
| issn |
2308-3425 |
| publishDate |
2021-02-01 |
| description |
Heart disease remains the single largest cause of death in developed countries, and novel therapeutic interventions are desperately needed to alleviate this growing burden. The cardiac lymphatic system is the long-overlooked counterpart of the coronary blood vasculature, but its important roles in homeostasis and disease are becoming increasingly apparent. Recently, the cardiac lymphatic vasculature in zebrafish has been described and its role in supporting the potent regenerative response of zebrafish heart tissue investigated. In this review, we discuss these findings in the wider context of lymphatic development, evolution and the promise of this system to open new therapeutic avenues to treat myocardial infarction and other cardiopathologies. |
| topic |
cardiac lymphatic vessels zebrafish heart development regeneration |
| url |
https://www.mdpi.com/2308-3425/8/2/21 |
| work_keys_str_mv |
AT xidifeng thelymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling AT stanislaotravisano thelymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling AT carolineapearson thelymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling AT chinglinglien thelymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling AT michaelrmharrison thelymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling AT xidifeng lymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling AT stanislaotravisano lymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling AT carolineapearson lymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling AT chinglinglien lymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling AT michaelrmharrison lymphaticsysteminzebrafishheartdevelopmentregenerationanddiseasemodeling |
| _version_ |
1724260240590897152 |