INVESTIGATION OF THE EFFECTS OF EXCIPIENTS ON TECHNOLOGICAL PROPERTIES OF COMPRESSION MIXTURE IN THE DEVELOPMENT OF TABLET TECHNOLOGY ROUND-LEAVED WINTERGREEN EXTRACT

• Main Authors: N. P. Darzuli, T. A. Hroshovyi, K. V. Sokolova, O. A. Podpletnia
• Format: Article
• Language: English
• Published: Ukrmedknyha Publishing House 2018-06-01
• Series: Фармацевтичний часопис
• Subjects: таблетки; фармако-технологічні показники порошкових мас; рослинні екстракти; грушанка круглолиста; математичне планування експерименту.
• Online Access: https://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/8995

The aim of the work. Investigation of the influence of substances on the technological properties of compression mixture for compressing in the development of tablets Pyrola Rotundifolia extract. Materials and Methods. Dry extract of round-leaved wintergreen and 27 excipients of five technological groups were used.  Studying of the influence of substances on the technological properties of the quality of tablets, such as: the angle of the natural slope, flowability, the bulk density of the compression mixture were carried out in accordance with the requirements of the State Pharmacopoeia. The tabletting process was evaluated on a five-point scale. Results and Discussion. Tablets was obtained by direct compression to study the effect of 27 substances on the technological properties of the compression mixture. The Greek-Latin cube of the 2nd order was used. The results of the dispersion analysis of the experiment showed that the best flow of compression mixture was provided by fructose, microcrystalline cellulose (MCC) 200, potato starch, neusilin US 2 and calcium stearate. The smallest value of the angle of natural slope of compression mixture was obtained using fructose, potato starch, MCC 302, neusilin US 2 and magnesium stearate. The greatest value of free bulk density compression mixture treated using sodium carboxymethyl starch, CompriM3, potato starch, calcium hydrogen phosphate anhydrous, MCC burst. The greatest value of bulk density after shrinkage Compri M3, potato starch, calcium hydrogen phosphate anhydrous, MCC burst. The best values of the Kara index were obtained using potato starch and fructose. The tablet compression process is best done with the use of tabletosis, parlitol 200SD, ludipress, procolv SMCC 90, MCC 200, vivapur 14, procolv EASYtab SP, vivapur 102. Conclusions. The influence of 27 excipients on the technological properties of compression mixture (the angle of the natural slope, flowability, the bulk density, process of tableting) were studied. The technological properties of the compression mixture of extract of round-leaved wintergreen and excipients indicate the ability to obtain tablets by direct compression.