Combination therapy with antioxidants improves total motile sperm counts: A Preliminary Study

• Main Authors: Kazutaka Terai, Shigeo Horie, Shinichiro Fukuhara, Yasushi Miyagawa, Kazuhiro Kobayashi, Akira Tsujimura
• Format: Article
• Language: English
• Published: Wiley 2020-01-01
• Series: Reproductive Medicine and Biology
• Subjects: antioxidant; hochu‐ekki‐to; male infertility; oligoasthenozoospermia; total motile sperm count
• Online Access: https://doi.org/10.1002/rmb2.12308
• ISSN: 1445-5781; 1447-0578

Abstract Purpose Optimal strategies to treat idiopathic male infertility have remained unclear. The aim of this study was to evaluate the effectiveness of combination antioxidant therapy with several vitamins and supplements on semen parameters. Methods Thirty‐one men with oligozoospermia and/or asthenozoospermia evaluated by a Makler counting chamber were randomly assigned to two treatment groups: a combination of antioxidant supplements (L‐carnitine, zinc, astaxanthin, coenzyme Q10, vitamin C, vitamin B12, and vitamin E) and a Chinese herbal medicine, hochu‐ekki‐to (HE). Serum endocrinological profiles and semen parameters, especially total motile sperm count, were compared between before and after 12 weeks of treatment in both groups. Results In the supplement group, endocrinological findings were not significantly improved. The semen parameters of semen volume, sperm concentration, and sperm motility were not statistically significantly improved, whereas total motile sperm count was significantly improved. In contrast, none of the endocrinological factors or semen findings were significantly improved by the Chinese herbal medicine although semen concentration, semen motility, and total motile sperm count showed a tendency to increase. Conclusion Because combination antioxidant therapy could improve sperm motility significantly for patients with idiopathic oligoasthenozoospermia, our supplement could be one treatment option for idiopathic male infertility.