Combination therapy with antioxidants improves total motile sperm counts: A Preliminary Study
Abstract Purpose Optimal strategies to treat idiopathic male infertility have remained unclear. The aim of this study was to evaluate the effectiveness of combination antioxidant therapy with several vitamins and supplements on semen parameters. Methods Thirty‐one men with oligozoospermia and/or ast...
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doaj-cd6125a71aef4201904596d62bcf2ea62020-11-25T02:12:30ZengWileyReproductive Medicine and Biology1445-57811447-05782020-01-01191899410.1002/rmb2.12308Combination therapy with antioxidants improves total motile sperm counts: A Preliminary StudyKazutaka Terai0Shigeo Horie1Shinichiro Fukuhara2Yasushi Miyagawa3Kazuhiro Kobayashi4Akira Tsujimura5Department of Urology Juntendo University Graduate School of Medicine Tokyo JapanDepartment of Urology Juntendo University Graduate School of Medicine Tokyo JapanDepartment of Urology Osaka University Graduate School of Medicine Osaka JapanDepartment of Urology Osaka University Graduate School of Medicine Osaka JapanMen's Health Clinic Tokyo Tokyo JapanMen's Health Clinic Tokyo Tokyo JapanAbstract Purpose Optimal strategies to treat idiopathic male infertility have remained unclear. The aim of this study was to evaluate the effectiveness of combination antioxidant therapy with several vitamins and supplements on semen parameters. Methods Thirty‐one men with oligozoospermia and/or asthenozoospermia evaluated by a Makler counting chamber were randomly assigned to two treatment groups: a combination of antioxidant supplements (L‐carnitine, zinc, astaxanthin, coenzyme Q10, vitamin C, vitamin B12, and vitamin E) and a Chinese herbal medicine, hochu‐ekki‐to (HE). Serum endocrinological profiles and semen parameters, especially total motile sperm count, were compared between before and after 12 weeks of treatment in both groups. Results In the supplement group, endocrinological findings were not significantly improved. The semen parameters of semen volume, sperm concentration, and sperm motility were not statistically significantly improved, whereas total motile sperm count was significantly improved. In contrast, none of the endocrinological factors or semen findings were significantly improved by the Chinese herbal medicine although semen concentration, semen motility, and total motile sperm count showed a tendency to increase. Conclusion Because combination antioxidant therapy could improve sperm motility significantly for patients with idiopathic oligoasthenozoospermia, our supplement could be one treatment option for idiopathic male infertility.https://doi.org/10.1002/rmb2.12308antioxidanthochu‐ekki‐tomale infertilityoligoasthenozoospermiatotal motile sperm count |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kazutaka Terai Shigeo Horie Shinichiro Fukuhara Yasushi Miyagawa Kazuhiro Kobayashi Akira Tsujimura |
spellingShingle |
Kazutaka Terai Shigeo Horie Shinichiro Fukuhara Yasushi Miyagawa Kazuhiro Kobayashi Akira Tsujimura Combination therapy with antioxidants improves total motile sperm counts: A Preliminary Study Reproductive Medicine and Biology antioxidant hochu‐ekki‐to male infertility oligoasthenozoospermia total motile sperm count |
author_facet |
Kazutaka Terai Shigeo Horie Shinichiro Fukuhara Yasushi Miyagawa Kazuhiro Kobayashi Akira Tsujimura |
author_sort |
Kazutaka Terai |
title |
Combination therapy with antioxidants improves total motile sperm counts: A Preliminary Study |
title_short |
Combination therapy with antioxidants improves total motile sperm counts: A Preliminary Study |
title_full |
Combination therapy with antioxidants improves total motile sperm counts: A Preliminary Study |
title_fullStr |
Combination therapy with antioxidants improves total motile sperm counts: A Preliminary Study |
title_full_unstemmed |
Combination therapy with antioxidants improves total motile sperm counts: A Preliminary Study |
title_sort |
combination therapy with antioxidants improves total motile sperm counts: a preliminary study |
publisher |
Wiley |
series |
Reproductive Medicine and Biology |
issn |
1445-5781 1447-0578 |
publishDate |
2020-01-01 |
description |
Abstract Purpose Optimal strategies to treat idiopathic male infertility have remained unclear. The aim of this study was to evaluate the effectiveness of combination antioxidant therapy with several vitamins and supplements on semen parameters. Methods Thirty‐one men with oligozoospermia and/or asthenozoospermia evaluated by a Makler counting chamber were randomly assigned to two treatment groups: a combination of antioxidant supplements (L‐carnitine, zinc, astaxanthin, coenzyme Q10, vitamin C, vitamin B12, and vitamin E) and a Chinese herbal medicine, hochu‐ekki‐to (HE). Serum endocrinological profiles and semen parameters, especially total motile sperm count, were compared between before and after 12 weeks of treatment in both groups. Results In the supplement group, endocrinological findings were not significantly improved. The semen parameters of semen volume, sperm concentration, and sperm motility were not statistically significantly improved, whereas total motile sperm count was significantly improved. In contrast, none of the endocrinological factors or semen findings were significantly improved by the Chinese herbal medicine although semen concentration, semen motility, and total motile sperm count showed a tendency to increase. Conclusion Because combination antioxidant therapy could improve sperm motility significantly for patients with idiopathic oligoasthenozoospermia, our supplement could be one treatment option for idiopathic male infertility. |
topic |
antioxidant hochu‐ekki‐to male infertility oligoasthenozoospermia total motile sperm count |
url |
https://doi.org/10.1002/rmb2.12308 |
work_keys_str_mv |
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