Development of a computational promoter with highly efficient expression in tumors

Development of a computational promoter with highly efficient expression in tumors

Abstract Background Gene therapy is a potent method to increase the therapeutic efficacy against cancer. However, a gene that is specifically expressed in the tumor area has not been identified. In addition, nonspecific expression of therapeutic genes in normal tissues may cause side effects that ca...

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Bibliographic Details
Main Authors: Shu-Yi Ho, Bo-Hau Chang, Chen-Han Chung, Yu-Ling Lin, Cheng-Hsun Chuang, Pei-Jung Hsieh, Wei-Chih Huang, Nu-Man Tsai, Sheng-Chieh Huang, Yen-Ku Liu, Yu-Chih Lo, Kuang-Wen Liao
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
Gene therapy
Transcription factor
HIF-1α
NF-κB and CREB
Online Access:http://link.springer.com/article/10.1186/s12885-018-4421-7

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http://link.springer.com/article/10.1186/s12885-018-4421-7

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