Proteomics for the Identification of Biomarkers in Testicular Cancer–Review
A large number of biomarkers have been proposed for the diagnosis of testicular cancer, representing putative molecular targets for anticancer treatments. However, no conclusive data have been provided. Proteomics represents a research field recently developed. It evaluates the large-scale analysis...
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doaj-cd68ad1b0f474aed98a2eba74808698a2020-11-25T00:37:46ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-07-011010.3389/fendo.2019.00462457412Proteomics for the Identification of Biomarkers in Testicular Cancer–ReviewDomenico Milardi0Domenico Milardi1Giuseppe Grande2Giuseppe Grande3Federica Vincenzoni4Federica Vincenzoni5Francesco Pierconti6Alfredo Pontecorvi7Alfredo Pontecorvi8International Scientific Institute “Paul VI”, Rome, ItalyDivision of Endocrinology, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, ItalyInternational Scientific Institute “Paul VI”, Rome, ItalyDivision of Endocrinology, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, ItalySchool of Medicine, Biochemistry and Clinical Biochemistry Institute, Catholic University of Rome, Rome, ItalyDepartment of Laboratory Diagnostic and Infectious Diseases, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, ItalyDivision of Anatomic Pathology and Histology, School of Medicine, Catholic University of Rome, Rome, ItalyInternational Scientific Institute “Paul VI”, Rome, ItalyDivision of Endocrinology, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, ItalyA large number of biomarkers have been proposed for the diagnosis of testicular cancer, representing putative molecular targets for anticancer treatments. However, no conclusive data have been provided. Proteomics represents a research field recently developed. It evaluates the large-scale analysis of the full protein components of a single cell, of a specific tissue, or of biological fluids. In the last decades, proteomics has been applied in clinical fields, thanks to modern technology and new bioinformatic tools, to identify novel molecular markers of diseases. The aim of this review is to argue the findings of recent studies in the discoveries of putative prognostic and diagnostic markers of testis cancer by proteomic techniques. We present here a panel of proteins identified by proteomics which might be used after validation for early detection and the prognostic evaluation of testicular tumors. In addition, the molecular mechanisms revealed by these proteomic studies might also guide the development of novel treatments in future.https://www.frontiersin.org/article/10.3389/fendo.2019.00462/fulltestis cancerproteomicsbiomarkergerm cell tumorproteins |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Domenico Milardi Domenico Milardi Giuseppe Grande Giuseppe Grande Federica Vincenzoni Federica Vincenzoni Francesco Pierconti Alfredo Pontecorvi Alfredo Pontecorvi |
spellingShingle |
Domenico Milardi Domenico Milardi Giuseppe Grande Giuseppe Grande Federica Vincenzoni Federica Vincenzoni Francesco Pierconti Alfredo Pontecorvi Alfredo Pontecorvi Proteomics for the Identification of Biomarkers in Testicular Cancer–Review Frontiers in Endocrinology testis cancer proteomics biomarker germ cell tumor proteins |
author_facet |
Domenico Milardi Domenico Milardi Giuseppe Grande Giuseppe Grande Federica Vincenzoni Federica Vincenzoni Francesco Pierconti Alfredo Pontecorvi Alfredo Pontecorvi |
author_sort |
Domenico Milardi |
title |
Proteomics for the Identification of Biomarkers in Testicular Cancer–Review |
title_short |
Proteomics for the Identification of Biomarkers in Testicular Cancer–Review |
title_full |
Proteomics for the Identification of Biomarkers in Testicular Cancer–Review |
title_fullStr |
Proteomics for the Identification of Biomarkers in Testicular Cancer–Review |
title_full_unstemmed |
Proteomics for the Identification of Biomarkers in Testicular Cancer–Review |
title_sort |
proteomics for the identification of biomarkers in testicular cancer–review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2019-07-01 |
description |
A large number of biomarkers have been proposed for the diagnosis of testicular cancer, representing putative molecular targets for anticancer treatments. However, no conclusive data have been provided. Proteomics represents a research field recently developed. It evaluates the large-scale analysis of the full protein components of a single cell, of a specific tissue, or of biological fluids. In the last decades, proteomics has been applied in clinical fields, thanks to modern technology and new bioinformatic tools, to identify novel molecular markers of diseases. The aim of this review is to argue the findings of recent studies in the discoveries of putative prognostic and diagnostic markers of testis cancer by proteomic techniques. We present here a panel of proteins identified by proteomics which might be used after validation for early detection and the prognostic evaluation of testicular tumors. In addition, the molecular mechanisms revealed by these proteomic studies might also guide the development of novel treatments in future. |
topic |
testis cancer proteomics biomarker germ cell tumor proteins |
url |
https://www.frontiersin.org/article/10.3389/fendo.2019.00462/full |
work_keys_str_mv |
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