Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis
CONTEXT: Zinc deficiency in children and adolescents impairs their growing, development and immune system. OBJECTIVE: To verify the existence of plasma and leukocyte zinc deficiency in adolescents with autoimmune hepatitis. METHODS: The study comprised 23 patients with autoimmune hepatitis, aged 10-...
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
2011-03-01
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doaj-cd7500f07d7244dfa59711e6ffc662252020-11-24T23:01:21ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-42192011-03-01481626510.1590/S0004-28032011000100013S0004-28032011000100013Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitisThalita Cremonesi Pereira0Margareth L. G. Saron1Wagner Alves de Carvalho2Maria Marluce Vilela3Nelci Fenalti Hoehr4Gabriel Hessel5Universidade Estadual de CampinasUniversidade Estadual de CampinasPontifícia Universidade Católica de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasCONTEXT: Zinc deficiency in children and adolescents impairs their growing, development and immune system. OBJECTIVE: To verify the existence of plasma and leukocyte zinc deficiency in adolescents with autoimmune hepatitis. METHODS: The study comprised 23 patients with autoimmune hepatitis, aged 10-18 years, assisted at the Ambulatory Service of Pediatric Hepatology of the University of Campinas Teaching Hospital, Campinas, SP, Brazil, and adolescents with ages compatible with the patients' ages comprised the control group. Sample of blood in both groups was collected for the analyses of plasma zinc and leukocyte zinc by atomic absorption spectrophotometry, beyond the nutritional status was evaluated in each adolescent. The following statistical tests were used: Mann-Whitney, Spearman's correlation and interclass concordance analysis. RESULTS:The significance level adopted was 5%. The average zinc level in plasma in patients was 71.91 ± 11.79 µg/dL and, in the control group, it was 80.74 ± 10.92 µg/dL, showing a significant difference (P = 0.04). The leukocyte zinc level in patients was 222.33 ± 166.13 pmol/10(6) cells and, in the control group, it was 226.64 ± 217.81 pmol/10(6) cells; there was no statistical significance between them (P = 0.45). CONCLUSION:The evaluation of the nutritional status showed that eutrophy is prevalent in patients, and they presented a higher body fat value than the control group, with a significant difference. More research is needed with adolescents with autoimmune hepatitis regarding levels of essential micronutrients, such as zinc, because a good nutritional status can improve the prognostic of liver disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032011000100013&lng=en&tlng=enHepatite autoimuneDeficiência de zincoEstado nutricionalAdolescenteCrianças |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thalita Cremonesi Pereira Margareth L. G. Saron Wagner Alves de Carvalho Maria Marluce Vilela Nelci Fenalti Hoehr Gabriel Hessel |
spellingShingle |
Thalita Cremonesi Pereira Margareth L. G. Saron Wagner Alves de Carvalho Maria Marluce Vilela Nelci Fenalti Hoehr Gabriel Hessel Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis Arquivos de Gastroenterologia Hepatite autoimune Deficiência de zinco Estado nutricional Adolescente Crianças |
author_facet |
Thalita Cremonesi Pereira Margareth L. G. Saron Wagner Alves de Carvalho Maria Marluce Vilela Nelci Fenalti Hoehr Gabriel Hessel |
author_sort |
Thalita Cremonesi Pereira |
title |
Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis |
title_short |
Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis |
title_full |
Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis |
title_fullStr |
Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis |
title_full_unstemmed |
Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis |
title_sort |
research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis |
publisher |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
series |
Arquivos de Gastroenterologia |
issn |
1678-4219 |
publishDate |
2011-03-01 |
description |
CONTEXT: Zinc deficiency in children and adolescents impairs their growing, development and immune system. OBJECTIVE: To verify the existence of plasma and leukocyte zinc deficiency in adolescents with autoimmune hepatitis. METHODS: The study comprised 23 patients with autoimmune hepatitis, aged 10-18 years, assisted at the Ambulatory Service of Pediatric Hepatology of the University of Campinas Teaching Hospital, Campinas, SP, Brazil, and adolescents with ages compatible with the patients' ages comprised the control group. Sample of blood in both groups was collected for the analyses of plasma zinc and leukocyte zinc by atomic absorption spectrophotometry, beyond the nutritional status was evaluated in each adolescent. The following statistical tests were used: Mann-Whitney, Spearman's correlation and interclass concordance analysis. RESULTS:The significance level adopted was 5%. The average zinc level in plasma in patients was 71.91 ± 11.79 µg/dL and, in the control group, it was 80.74 ± 10.92 µg/dL, showing a significant difference (P = 0.04). The leukocyte zinc level in patients was 222.33 ± 166.13 pmol/10(6) cells and, in the control group, it was 226.64 ± 217.81 pmol/10(6) cells; there was no statistical significance between them (P = 0.45). CONCLUSION:The evaluation of the nutritional status showed that eutrophy is prevalent in patients, and they presented a higher body fat value than the control group, with a significant difference. More research is needed with adolescents with autoimmune hepatitis regarding levels of essential micronutrients, such as zinc, because a good nutritional status can improve the prognostic of liver disease. |
topic |
Hepatite autoimune Deficiência de zinco Estado nutricional Adolescente Crianças |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032011000100013&lng=en&tlng=en |
work_keys_str_mv |
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