Integrated multi-biomarker responses of juvenile rainbow trout (Oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixture
Pharmaceuticals are emerging pollutants of concern for aquatic ecosystems where they are occurring in complex mixtures. In the present study, the chronic toxicity of an environmentally relevant pharmaceutical mixture on juvenile rainbow trout (Oncorhynchus mykiss) was investigated. Five pharmaceutic...
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2021-09-01
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doaj-cd754854d51442da8dac25f2d3f26c1f2021-07-05T04:13:32ZengElsevierEcotoxicology and Environmental Safety0147-65132021-09-01221112454Integrated multi-biomarker responses of juvenile rainbow trout (Oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixtureMahaut Beghin0Mélodie Schmitz1Stéphane Betoulle2Olivier Palluel3Sébastien Baekelandt4Syaghalirwa N.M. Mandiki5Erin Gillet6Katherine Nott7Jean-Marc Porcher8Christelle Robert9Sébastien Ronkart10Patrick Kestemont11Research Unit in Environmental and Evolutionary Biology (URBE), Institute of Life, Earth and Environment, University of Namur, 61 Rue de Bruxelles, B-5000 Namur, Belgium; Corresponding author.Research Unit in Environmental and Evolutionary Biology (URBE), Institute of Life, Earth and Environment, University of Namur, 61 Rue de Bruxelles, B-5000 Namur, BelgiumUniversité de Reims Champagne-Ardennes, Stress Environnementaux et BIOsurveillance des milieux aquatiques, Campus du Moulin de la Housse, BP 1039, 51687 Reims cedex 2, FranceInstitut national de l'environnement industriel et des risques (INERIS), URM-I-02 SEBIO, BP no. 2, 60550 Verneuil en Halatte, FranceResearch Unit in Environmental and Evolutionary Biology (URBE), Institute of Life, Earth and Environment, University of Namur, 61 Rue de Bruxelles, B-5000 Namur, BelgiumResearch Unit in Environmental and Evolutionary Biology (URBE), Institute of Life, Earth and Environment, University of Namur, 61 Rue de Bruxelles, B-5000 Namur, BelgiumLa Société wallonne des eaux, 41 Rue de la Concorde, B-4800 Verviers, BelgiumLa Société wallonne des eaux, 41 Rue de la Concorde, B-4800 Verviers, BelgiumInstitut national de l'environnement industriel et des risques (INERIS), URM-I-02 SEBIO, BP no. 2, 60550 Verneuil en Halatte, FranceCentre d'Economie Rurale, Health Department, 8 Rue Point du Jour, B-6900 Marloie, BelgiumLa Société wallonne des eaux, 41 Rue de la Concorde, B-4800 Verviers, BelgiumResearch Unit in Environmental and Evolutionary Biology (URBE), Institute of Life, Earth and Environment, University of Namur, 61 Rue de Bruxelles, B-5000 Namur, BelgiumPharmaceuticals are emerging pollutants of concern for aquatic ecosystems where they are occurring in complex mixtures. In the present study, the chronic toxicity of an environmentally relevant pharmaceutical mixture on juvenile rainbow trout (Oncorhynchus mykiss) was investigated. Five pharmaceuticals (paracetamol, carbamazepine, diclofenac, naproxen and irbesartan) were selected based on their detection frequency and concentration levels in the Meuse river (Belgium). Fish were exposed for 42 days to three different concentrations of the mixture, the median one detected in the Meuse river, 10-times and 100-times this concentration. Effects on the nervous, immune, antioxidant, and detoxification systems were evaluated throughout the exposure period and their response standardized using the Integrated Biomarker Response (IBRv2) index. IBRv2 scores increased over time in the fish exposed to the highest concentration. After 42 days, fish exposed to the highest concentration displayed significantly higher levels in lysozyme activity (p < 0.01). The mixture also caused significant changes in brain serotonin turnover (p < 0.05). In short, our results indicate that the subchronic waterborne exposure to a pharmaceutical mixture commonly occurring in freshwater ecosystems may affect the neuroendocrine and immune systems of juvenile rainbow trout.http://www.sciencedirect.com/science/article/pii/S0147651321005662DrugsCocktailFishImmunityNeurotoxicityIBR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahaut Beghin Mélodie Schmitz Stéphane Betoulle Olivier Palluel Sébastien Baekelandt Syaghalirwa N.M. Mandiki Erin Gillet Katherine Nott Jean-Marc Porcher Christelle Robert Sébastien Ronkart Patrick Kestemont |
spellingShingle |
Mahaut Beghin Mélodie Schmitz Stéphane Betoulle Olivier Palluel Sébastien Baekelandt Syaghalirwa N.M. Mandiki Erin Gillet Katherine Nott Jean-Marc Porcher Christelle Robert Sébastien Ronkart Patrick Kestemont Integrated multi-biomarker responses of juvenile rainbow trout (Oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixture Ecotoxicology and Environmental Safety Drugs Cocktail Fish Immunity Neurotoxicity IBR |
author_facet |
Mahaut Beghin Mélodie Schmitz Stéphane Betoulle Olivier Palluel Sébastien Baekelandt Syaghalirwa N.M. Mandiki Erin Gillet Katherine Nott Jean-Marc Porcher Christelle Robert Sébastien Ronkart Patrick Kestemont |
author_sort |
Mahaut Beghin |
title |
Integrated multi-biomarker responses of juvenile rainbow trout (Oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixture |
title_short |
Integrated multi-biomarker responses of juvenile rainbow trout (Oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixture |
title_full |
Integrated multi-biomarker responses of juvenile rainbow trout (Oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixture |
title_fullStr |
Integrated multi-biomarker responses of juvenile rainbow trout (Oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixture |
title_full_unstemmed |
Integrated multi-biomarker responses of juvenile rainbow trout (Oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixture |
title_sort |
integrated multi-biomarker responses of juvenile rainbow trout (oncorhynchus mykiss) to an environmentally relevant pharmaceutical mixture |
publisher |
Elsevier |
series |
Ecotoxicology and Environmental Safety |
issn |
0147-6513 |
publishDate |
2021-09-01 |
description |
Pharmaceuticals are emerging pollutants of concern for aquatic ecosystems where they are occurring in complex mixtures. In the present study, the chronic toxicity of an environmentally relevant pharmaceutical mixture on juvenile rainbow trout (Oncorhynchus mykiss) was investigated. Five pharmaceuticals (paracetamol, carbamazepine, diclofenac, naproxen and irbesartan) were selected based on their detection frequency and concentration levels in the Meuse river (Belgium). Fish were exposed for 42 days to three different concentrations of the mixture, the median one detected in the Meuse river, 10-times and 100-times this concentration. Effects on the nervous, immune, antioxidant, and detoxification systems were evaluated throughout the exposure period and their response standardized using the Integrated Biomarker Response (IBRv2) index. IBRv2 scores increased over time in the fish exposed to the highest concentration. After 42 days, fish exposed to the highest concentration displayed significantly higher levels in lysozyme activity (p < 0.01). The mixture also caused significant changes in brain serotonin turnover (p < 0.05). In short, our results indicate that the subchronic waterborne exposure to a pharmaceutical mixture commonly occurring in freshwater ecosystems may affect the neuroendocrine and immune systems of juvenile rainbow trout. |
topic |
Drugs Cocktail Fish Immunity Neurotoxicity IBR |
url |
http://www.sciencedirect.com/science/article/pii/S0147651321005662 |
work_keys_str_mv |
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