Identification of Small-Molecule Inhibitors against Meso-2, 6-Diaminopimelate Dehydrogenase from Porphyromonas gingivalis.
Species-specific antimicrobial therapy has the potential to combat the increasing threat of antibiotic resistance and alteration of the human microbiome. We therefore set out to demonstrate the beginning of a pathogen-selective drug discovery method using the periodontal pathogen Porphyromonas gingi...
Main Authors: | Victoria N Stone, Hardik I Parikh, Fadi El-rami, Xiuchun Ge, Weihau Chen, Yan Zhang, Glen E Kellogg, Ping Xu |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4636305?pdf=render |
Similar Items
-
Identification and functional characterization of NAD(P)+‐dependent meso‐diaminopimelate dehydrogenase from Numidum massiliense
by: Hironaga Akita, et al.
Published: (2020-08-01) -
Genomic and biochemical analysis of the diaminopimelate and lysine biosynthesis pathway in Verrucomicrobium spinosum: Identification and partial characterization of L,L-diaminopimelate aminotransferase and UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-meso-diaminopimelate ligase
by: Victoria R. Nachar, et al.
Published: (2012-05-01) -
Porphyromonas gingivalis fimbriae
by: Morten Enersen, et al.
Published: (2013-05-01) -
Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase
by: Xida Zhao, et al.
Published: (2021-09-01) -
A Novel Antimicrobial Drug Discovery Approach for the Periodontal Pathogen Porphyromonas gingivalis
by: Stone, Victoria N
Published: (2015)