A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

Epigenetic changes can drive drug resistance in cancer. Here, the authors show that in BET inhibitor resistant leukaemia cells, genome-wide enhancer remodelling drives therapeutic resistance and targeting enhancer plasticity may overcome this resistance.

Bibliographic Details
Main Authors: Lei Guo, Jia Li, Hongxiang Zeng, Anna G. Guzman, Tingting Li, Minjung Lee, Yubin Zhou, Margaret A. Goodell, Clifford Stephan, Peter J. A. Davies, Mark A Dawson, Deqiang Sun, Yun Huang
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14604-6

Internet

https://doi.org/10.1038/s41467-020-14604-6

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