Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy
Abstract Background FIGHTDIGO study has shown the feasibility of handgrip strength (HGS) measurements in 201 consecutive digestive cancer patients undergoing chemotherapy. Objective This study focuses on a secondary aim of FIGHTDIGO study: the relationship between muscle mass and HGS. Design Two con...
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doaj-cd9db15ffc774880b7b5a4cb32fe5f1a2020-11-24T21:52:02ZengWileyCancer Medicine2045-76342019-07-01883677368410.1002/cam4.2238Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapyJohanna Moreau0Marie‐Amélie Ordan1Coralie Barbe2Camille Mazza3Marine Perrier4Damien Botsen5Mathilde Brasseur6Christophe Portefaix7Yohann Renard8Barbara Tallière9Eric Bertin10Christine Hoeffel11Olivier Bouché12Ambulatory Care Unit Reims University Hospital Reims FranceAmbulatory Care Unit Reims University Hospital Reims FranceDepartment of Biostatistics Reims University Hospital Reims FranceAmbulatory Care Unit Reims University Hospital Reims FranceAmbulatory Care Unit Reims University Hospital Reims FranceAmbulatory Care Unit Reims University Hospital Reims FranceAmbulatory Care Unit Reims University Hospital Reims FranceDepartment of Radiology Reims University Hospital Reims FranceDepartment of General and Digestive Surgey Reims University Hospital Reims FranceArtificial Nutrition Unit Reims University Hospital Reims FranceDepartment of Nutrition, Endocrinology, and Diabétology Reims University Hospital Reims FranceDepartment of Radiology Reims University Hospital Reims FranceAmbulatory Care Unit Reims University Hospital Reims FranceAbstract Background FIGHTDIGO study has shown the feasibility of handgrip strength (HGS) measurements in 201 consecutive digestive cancer patients undergoing chemotherapy. Objective This study focuses on a secondary aim of FIGHTDIGO study: the relationship between muscle mass and HGS. Design Two consecutive bilateral measures of HGS were performed using a Jamar dynamometer before the start of each chemotherapy. The highest value was chosen for final evaluation. Dynapenia (loss of muscle strength) was defined as HGS < 30 kg (men) and < 20 kg (women). Muscle mass was measured at lumbar level (L3) on Computed Tomography (CT) scans performed less than 3 weeks before or after the measurement of HGS. Muscle mass loss was defined by skeletal muscle index (SMI) < 53 cm2/m2 (in men with a body mass index (BMI)> 25 kg/m2), < 43 cm2/m2 (in men with a BMI < 25 kg/m2), and < 41 cm2/m2 (in women regardless of BMI). Sarcopenia was defined by the association of a dynapenia and a loss of muscle mass. Results A total of 150 patients were included in this analysis (mean age: 65.6 ± 10.9 years, 87 males (58%), colorectal cancer (47.3%), metastatic stage (76.7%)). A total of 348 CT scans were evaluated. For the 348 measurements, mean SMI and HGS were 41.8 ± 8.7 cm2/m2 and 32.1 ± 11.0 kg, respectively. Muscle mass loss, dynapenia, or sarcopenia were reported at least once, in 120 (80%), 45 (30%), and 30 (20%) patients, respectively. SMI was significantly correlated with HGS (Pearson coefficient = 0.53, P < 0.0001). At concordance analysis, 188 dyad SMI/HGS (54%) were in agreement (Kappa = 0.14 [95% CI, 0.07‐0.21]). Conclusion Correlation between the measurements of HGS and SMI is strong but the concordance between dynapenia and muscle mass loss is poor. Further studies should be performed to confirm the diagnostic thresholds, and to study the chronology of dynapenia and loss of muscle mass.https://doi.org/10.1002/cam4.2238dynapeniasarcopeniamuscle strengthmuscle massdigestive system neoplasms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Johanna Moreau Marie‐Amélie Ordan Coralie Barbe Camille Mazza Marine Perrier Damien Botsen Mathilde Brasseur Christophe Portefaix Yohann Renard Barbara Tallière Eric Bertin Christine Hoeffel Olivier Bouché |
spellingShingle |
Johanna Moreau Marie‐Amélie Ordan Coralie Barbe Camille Mazza Marine Perrier Damien Botsen Mathilde Brasseur Christophe Portefaix Yohann Renard Barbara Tallière Eric Bertin Christine Hoeffel Olivier Bouché Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy Cancer Medicine dynapenia sarcopenia muscle strength muscle mass digestive system neoplasms |
author_facet |
Johanna Moreau Marie‐Amélie Ordan Coralie Barbe Camille Mazza Marine Perrier Damien Botsen Mathilde Brasseur Christophe Portefaix Yohann Renard Barbara Tallière Eric Bertin Christine Hoeffel Olivier Bouché |
author_sort |
Johanna Moreau |
title |
Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy |
title_short |
Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy |
title_full |
Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy |
title_fullStr |
Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy |
title_full_unstemmed |
Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy |
title_sort |
correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2019-07-01 |
description |
Abstract Background FIGHTDIGO study has shown the feasibility of handgrip strength (HGS) measurements in 201 consecutive digestive cancer patients undergoing chemotherapy. Objective This study focuses on a secondary aim of FIGHTDIGO study: the relationship between muscle mass and HGS. Design Two consecutive bilateral measures of HGS were performed using a Jamar dynamometer before the start of each chemotherapy. The highest value was chosen for final evaluation. Dynapenia (loss of muscle strength) was defined as HGS < 30 kg (men) and < 20 kg (women). Muscle mass was measured at lumbar level (L3) on Computed Tomography (CT) scans performed less than 3 weeks before or after the measurement of HGS. Muscle mass loss was defined by skeletal muscle index (SMI) < 53 cm2/m2 (in men with a body mass index (BMI)> 25 kg/m2), < 43 cm2/m2 (in men with a BMI < 25 kg/m2), and < 41 cm2/m2 (in women regardless of BMI). Sarcopenia was defined by the association of a dynapenia and a loss of muscle mass. Results A total of 150 patients were included in this analysis (mean age: 65.6 ± 10.9 years, 87 males (58%), colorectal cancer (47.3%), metastatic stage (76.7%)). A total of 348 CT scans were evaluated. For the 348 measurements, mean SMI and HGS were 41.8 ± 8.7 cm2/m2 and 32.1 ± 11.0 kg, respectively. Muscle mass loss, dynapenia, or sarcopenia were reported at least once, in 120 (80%), 45 (30%), and 30 (20%) patients, respectively. SMI was significantly correlated with HGS (Pearson coefficient = 0.53, P < 0.0001). At concordance analysis, 188 dyad SMI/HGS (54%) were in agreement (Kappa = 0.14 [95% CI, 0.07‐0.21]). Conclusion Correlation between the measurements of HGS and SMI is strong but the concordance between dynapenia and muscle mass loss is poor. Further studies should be performed to confirm the diagnostic thresholds, and to study the chronology of dynapenia and loss of muscle mass. |
topic |
dynapenia sarcopenia muscle strength muscle mass digestive system neoplasms |
url |
https://doi.org/10.1002/cam4.2238 |
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