Interleukin-6 Could Be a Potential Prognostic Factor in Ambulatory Elderly Patients with Stable Heart Failure: Results from a Pilot Study
Introduction: Inflammation is a fundamental phenomenon in heart failure, but the prognostic or therapeutic role of markers such as interleukin-6 (IL-6) has not yet been clarified. The objective of this study is to describe the clinical profile of patients with elevated IL-6 and determine if they hav...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/10/3/504 |
id |
doaj-cdaaa3e14d2e463c8d740d99ec3face2 |
---|---|
record_format |
Article |
spelling |
doaj-cdaaa3e14d2e463c8d740d99ec3face22021-02-02T00:01:05ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-011050450410.3390/jcm10030504Interleukin-6 Could Be a Potential Prognostic Factor in Ambulatory Elderly Patients with Stable Heart Failure: Results from a Pilot StudyMarina Povar-Echeverría0Pablo Esteban Auquilla-Clavijo1Emmanuel Andrès2Francisco Javier Martin-Sánchez3María Victoria Laguna-Calle4Alberto Elpidio Calvo-Elías5Noel Lorenzo-Villalba6Manuel Méndez-Bailón7Servicio de Medicina Interna, Hospital Universitario Miguel Servet, 50009 Zaragoza, SpainServicio de Cardiología, Hospital Royo Villanova, 50015 Zaragoza, SpainService de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, FranceServicio de Medicina Interna, Facultad de Medicina, Instituto de Investigación Sanitaria del Hospital San Carlos, Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainServicio de Medicina Interna, Facultad de Medicina, Instituto de Investigación Sanitaria del Hospital San Carlos, Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainServicio de Medicina Interna, Facultad de Medicina, Instituto de Investigación Sanitaria del Hospital San Carlos, Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainService de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, FranceServicio de Medicina Interna, Facultad de Medicina, Instituto de Investigación Sanitaria del Hospital San Carlos, Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, SpainIntroduction: Inflammation is a fundamental phenomenon in heart failure, but the prognostic or therapeutic role of markers such as interleukin-6 (IL-6) has not yet been clarified. The objective of this study is to describe the clinical profile of patients with elevated IL-6 and determine if they have worse clinical outcomes. Methods: A retrospective c.ohort observational study including 78 patients with heart failure followed up at the Heart Failure Outpatient Clinic of the Internal Medicine Department. IL-6 was determined in all patients, who were then assigned into two groups according to IL-6 level (normal or high). Clinical and prognostic data were collected to determine the differences in both groups. Results: The average age was 79 years, 60% female. A total of 53.8% of the patients had elevated IL-6 (group 2). Patients with elevated IL-6 presented more frequently with anemia mellitus (64.3% vs. 41.7%; <i>p</i> = 0.046), atrial fibrillation (83.3% vs. 61.9% <i>p</i> = 0.036), dyslipidemia (76.2% vs. 58.2%; <i>p</i> = 0.03), higher creatinine levels (1.35 mg/dL vs. 1.08 mg/dL; <i>p</i> = 0.024), lower glomerular filtration rate (43.6 mL/min/m<sup>2</sup> vs. 59.9 mL/min/m<sup>2</sup>; <i>p</i> = 0.007), and anemia 25% vs. 52.4% <i>p</i> = 0.014. The factors independently associated with the increase in IL-6 were anemia 3.513 (1.163–10.607) and renal failure 0.963 (0.936–0.991), <i>p</i> < 0.05. Mortality was higher in the group with elevated IL-6 levels (16% vs. 2%; <i>p</i> = 0.044) with a log-rank <i>p</i> = 0.027 in the Kaplan–Meier curve. Conclusion: Patients with heart failure and elevated IL-6 most often have atrial fibrillation, diabetes mellitus, dyslipidemia, anemia, and renal failure. In addition, mortality was higher and a tendency of higher hospital admission was observed in stable HF patients with elevated IL-6.https://www.mdpi.com/2077-0383/10/3/504heart failurebiomarkersinflammationsinterleukin-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marina Povar-Echeverría Pablo Esteban Auquilla-Clavijo Emmanuel Andrès Francisco Javier Martin-Sánchez María Victoria Laguna-Calle Alberto Elpidio Calvo-Elías Noel Lorenzo-Villalba Manuel Méndez-Bailón |
spellingShingle |
Marina Povar-Echeverría Pablo Esteban Auquilla-Clavijo Emmanuel Andrès Francisco Javier Martin-Sánchez María Victoria Laguna-Calle Alberto Elpidio Calvo-Elías Noel Lorenzo-Villalba Manuel Méndez-Bailón Interleukin-6 Could Be a Potential Prognostic Factor in Ambulatory Elderly Patients with Stable Heart Failure: Results from a Pilot Study Journal of Clinical Medicine heart failure biomarkers inflammations interleukin-6 |
author_facet |
Marina Povar-Echeverría Pablo Esteban Auquilla-Clavijo Emmanuel Andrès Francisco Javier Martin-Sánchez María Victoria Laguna-Calle Alberto Elpidio Calvo-Elías Noel Lorenzo-Villalba Manuel Méndez-Bailón |
author_sort |
Marina Povar-Echeverría |
title |
Interleukin-6 Could Be a Potential Prognostic Factor in Ambulatory Elderly Patients with Stable Heart Failure: Results from a Pilot Study |
title_short |
Interleukin-6 Could Be a Potential Prognostic Factor in Ambulatory Elderly Patients with Stable Heart Failure: Results from a Pilot Study |
title_full |
Interleukin-6 Could Be a Potential Prognostic Factor in Ambulatory Elderly Patients with Stable Heart Failure: Results from a Pilot Study |
title_fullStr |
Interleukin-6 Could Be a Potential Prognostic Factor in Ambulatory Elderly Patients with Stable Heart Failure: Results from a Pilot Study |
title_full_unstemmed |
Interleukin-6 Could Be a Potential Prognostic Factor in Ambulatory Elderly Patients with Stable Heart Failure: Results from a Pilot Study |
title_sort |
interleukin-6 could be a potential prognostic factor in ambulatory elderly patients with stable heart failure: results from a pilot study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-02-01 |
description |
Introduction: Inflammation is a fundamental phenomenon in heart failure, but the prognostic or therapeutic role of markers such as interleukin-6 (IL-6) has not yet been clarified. The objective of this study is to describe the clinical profile of patients with elevated IL-6 and determine if they have worse clinical outcomes. Methods: A retrospective c.ohort observational study including 78 patients with heart failure followed up at the Heart Failure Outpatient Clinic of the Internal Medicine Department. IL-6 was determined in all patients, who were then assigned into two groups according to IL-6 level (normal or high). Clinical and prognostic data were collected to determine the differences in both groups. Results: The average age was 79 years, 60% female. A total of 53.8% of the patients had elevated IL-6 (group 2). Patients with elevated IL-6 presented more frequently with anemia mellitus (64.3% vs. 41.7%; <i>p</i> = 0.046), atrial fibrillation (83.3% vs. 61.9% <i>p</i> = 0.036), dyslipidemia (76.2% vs. 58.2%; <i>p</i> = 0.03), higher creatinine levels (1.35 mg/dL vs. 1.08 mg/dL; <i>p</i> = 0.024), lower glomerular filtration rate (43.6 mL/min/m<sup>2</sup> vs. 59.9 mL/min/m<sup>2</sup>; <i>p</i> = 0.007), and anemia 25% vs. 52.4% <i>p</i> = 0.014. The factors independently associated with the increase in IL-6 were anemia 3.513 (1.163–10.607) and renal failure 0.963 (0.936–0.991), <i>p</i> < 0.05. Mortality was higher in the group with elevated IL-6 levels (16% vs. 2%; <i>p</i> = 0.044) with a log-rank <i>p</i> = 0.027 in the Kaplan–Meier curve. Conclusion: Patients with heart failure and elevated IL-6 most often have atrial fibrillation, diabetes mellitus, dyslipidemia, anemia, and renal failure. In addition, mortality was higher and a tendency of higher hospital admission was observed in stable HF patients with elevated IL-6. |
topic |
heart failure biomarkers inflammations interleukin-6 |
url |
https://www.mdpi.com/2077-0383/10/3/504 |
work_keys_str_mv |
AT marinapovarecheverria interleukin6couldbeapotentialprognosticfactorinambulatoryelderlypatientswithstableheartfailureresultsfromapilotstudy AT pabloestebanauquillaclavijo interleukin6couldbeapotentialprognosticfactorinambulatoryelderlypatientswithstableheartfailureresultsfromapilotstudy AT emmanuelandres interleukin6couldbeapotentialprognosticfactorinambulatoryelderlypatientswithstableheartfailureresultsfromapilotstudy AT franciscojaviermartinsanchez interleukin6couldbeapotentialprognosticfactorinambulatoryelderlypatientswithstableheartfailureresultsfromapilotstudy AT mariavictorialagunacalle interleukin6couldbeapotentialprognosticfactorinambulatoryelderlypatientswithstableheartfailureresultsfromapilotstudy AT albertoelpidiocalvoelias interleukin6couldbeapotentialprognosticfactorinambulatoryelderlypatientswithstableheartfailureresultsfromapilotstudy AT noellorenzovillalba interleukin6couldbeapotentialprognosticfactorinambulatoryelderlypatientswithstableheartfailureresultsfromapilotstudy AT manuelmendezbailon interleukin6couldbeapotentialprognosticfactorinambulatoryelderlypatientswithstableheartfailureresultsfromapilotstudy |
_version_ |
1724314858559635456 |