Vitamin D deficiency in patients with cluster headache: a preliminary study
Abstract Background Cluster headache is famous for attacks with seasonal and diurnal periodicity. This diurnal and seasonal variation might be related to sunlight and vitamin D metabolism. We investigated the serum vitamin D levels in patients with cluster headache. Methods We enrolled patients with...
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doaj-cdae11dc627d47c0b74f1150b63aa0ee2020-11-25T01:20:31ZengBMCThe Journal of Headache and Pain1129-23691129-23772018-07-011911710.1186/s10194-018-0886-7Vitamin D deficiency in patients with cluster headache: a preliminary studyJong-Hee Sohn0Min-Kyung Chu1Kwang-Yeol Park2Hong-Yup Ahn3Soo-Jin Cho4Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of MedicineDepartment of Neurology, Severance Hospital, Yonsei University College of MedicineDepartment of Neurology, Chung-Ang University Hospital, Chung-Ang University College of MedicineDepartment of Statistics, Dongguk University-SeoulDepartment of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of MedicineAbstract Background Cluster headache is famous for attacks with seasonal and diurnal periodicity. This diurnal and seasonal variation might be related to sunlight and vitamin D metabolism. We investigated the serum vitamin D levels in patients with cluster headache. Methods We enrolled patients with cluster headache and age- and sex-matched migraineurs and normal controls. From October 2016 to March 2018, non-fasting serum 25(OH)D concentrations were measured using a chemiluminescent immunoassay. Vitamin D deficiency was defined as a concentration < 20 ng/mL. Results The study enrolled 28 patients with cluster headache, 36 migraineurs, and 36 normal controls. In the patients with cluster headache, the serum 25(OH)D concentration averaged 14.0 ± 3.9 ng/mL and 92.8% had vitamin D deficiency. There was no significant difference among the patients with cluster headache, migraineurs, and controls. In the patients with cluster headache, there was no difference in the serum 25(OH)D concentrations between men and women, cluster and remission periods, first and recurrent attack, presence and absence of daily or seasonal periodicity, and 3-month recurrence. In the 14 patients with seasonal periodicity, patients with periodicity of winter to spring had a trend of lower serum 25(OH)D concentrations than those with periodicity of summer to autumn (12.30 ± 1.58 vs. 16.96 ± 4.69 ng/mL, p = 0.097). Conclusions Vitamin D deficiency is common in patients with cluster headache, but the role of vitamin D deficiency is uncertain, except for its seasonal influence.http://link.springer.com/article/10.1186/s10194-018-0886-7Vitamin DDeficiencyCluster headacheMigraine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jong-Hee Sohn Min-Kyung Chu Kwang-Yeol Park Hong-Yup Ahn Soo-Jin Cho |
spellingShingle |
Jong-Hee Sohn Min-Kyung Chu Kwang-Yeol Park Hong-Yup Ahn Soo-Jin Cho Vitamin D deficiency in patients with cluster headache: a preliminary study The Journal of Headache and Pain Vitamin D Deficiency Cluster headache Migraine |
author_facet |
Jong-Hee Sohn Min-Kyung Chu Kwang-Yeol Park Hong-Yup Ahn Soo-Jin Cho |
author_sort |
Jong-Hee Sohn |
title |
Vitamin D deficiency in patients with cluster headache: a preliminary study |
title_short |
Vitamin D deficiency in patients with cluster headache: a preliminary study |
title_full |
Vitamin D deficiency in patients with cluster headache: a preliminary study |
title_fullStr |
Vitamin D deficiency in patients with cluster headache: a preliminary study |
title_full_unstemmed |
Vitamin D deficiency in patients with cluster headache: a preliminary study |
title_sort |
vitamin d deficiency in patients with cluster headache: a preliminary study |
publisher |
BMC |
series |
The Journal of Headache and Pain |
issn |
1129-2369 1129-2377 |
publishDate |
2018-07-01 |
description |
Abstract Background Cluster headache is famous for attacks with seasonal and diurnal periodicity. This diurnal and seasonal variation might be related to sunlight and vitamin D metabolism. We investigated the serum vitamin D levels in patients with cluster headache. Methods We enrolled patients with cluster headache and age- and sex-matched migraineurs and normal controls. From October 2016 to March 2018, non-fasting serum 25(OH)D concentrations were measured using a chemiluminescent immunoassay. Vitamin D deficiency was defined as a concentration < 20 ng/mL. Results The study enrolled 28 patients with cluster headache, 36 migraineurs, and 36 normal controls. In the patients with cluster headache, the serum 25(OH)D concentration averaged 14.0 ± 3.9 ng/mL and 92.8% had vitamin D deficiency. There was no significant difference among the patients with cluster headache, migraineurs, and controls. In the patients with cluster headache, there was no difference in the serum 25(OH)D concentrations between men and women, cluster and remission periods, first and recurrent attack, presence and absence of daily or seasonal periodicity, and 3-month recurrence. In the 14 patients with seasonal periodicity, patients with periodicity of winter to spring had a trend of lower serum 25(OH)D concentrations than those with periodicity of summer to autumn (12.30 ± 1.58 vs. 16.96 ± 4.69 ng/mL, p = 0.097). Conclusions Vitamin D deficiency is common in patients with cluster headache, but the role of vitamin D deficiency is uncertain, except for its seasonal influence. |
topic |
Vitamin D Deficiency Cluster headache Migraine |
url |
http://link.springer.com/article/10.1186/s10194-018-0886-7 |
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