Transcranial Direct Current Stimulation Enhances Sucking of a Liquid Bolus in Healthy Humans
Background: Transcranial direct current stimulation (tDCS) is a non-invasive technique used for modulating cortical excitability in vivo in humans. Here we evaluated the effect of tDCS on behavioral and electrophysiological aspects of physiological sucking and swallowing. Methods: Twelve healthy sub...
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doaj-cdb62c2416ec4e118e130e742540f80e2021-03-18T04:38:18ZengElsevierBrain Stimulation1935-861X2014-11-0176817822Transcranial Direct Current Stimulation Enhances Sucking of a Liquid Bolus in Healthy HumansGiuseppe Cosentino0Enrico Alfonsi1Filippo Brighina2Mauro Fresia3Brigida Fierro4Giorgio Sandrini5Antonio Schindler6Francesca Valentino7Danilo Fontana8Alberto Priori9Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, ItalyDepartment of Neurophysiopathology, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy; Corresponding author. Via Mondino n. 2, 27100 Pavia, Italy. Tel.: +39 0382380434; fax: +39 0382380286.Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, ItalyDepartment of Neurophysiopathology, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, ItalyDepartment of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, ItalyDepartment of Neurophysiopathology, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy; Department of Brain and Behaviour, University of Pavia, ItalyDepartment of Clinical Sciences “L. Sacco”, University of Milan, ItalyDepartment of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, ItalyDepartment of Neurophysiopathology, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, ItalyDepartment of Neurological Sciences, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, ItalyBackground: Transcranial direct current stimulation (tDCS) is a non-invasive technique used for modulating cortical excitability in vivo in humans. Here we evaluated the effect of tDCS on behavioral and electrophysiological aspects of physiological sucking and swallowing. Methods: Twelve healthy subjects underwent three tDCS sessions (anodal, cathodal and sham stimulation) on separate days in a double-blind randomized order. The active electrode was placed over the right swallowing motor cortex. Repeated sucking and swallowing acts were performed at baseline and at 15 and 60 min after each tDCS session and the mean liquid bolus volume ingested at each time point was measured. We also calculated average values of the following electrophysiological parameters: 1) area and 2) duration of the rectified EMG signal from the suprahyoid/submental muscles related to the sucking and swallowing phases; 3) EMG peak amplitude for the sucking and swallowing phases; 4) area and peak amplitude of the laryngeal-pharyngeal mechanogram; 5) oropharyngeal delay. Results: The volume of the ingested bolus significantly increased (by an average of about 30% compared with the baseline value) both at 15 and at 60 min after the end of anodal tDCS. The electrophysiological evaluation after anodal tDCS showed a significant increase in area and duration of the sucking phase-related EMG signal. Conclusions: Anodal tDCS leads to stronger sucking of a liquid bolus in healthy subjects, likely by increasing recruitment of cortical areas of the swallowing network. This finding might open up interesting perspectives for the treatment of patients suffering from dysphagia due to various pathological conditions.http://www.sciencedirect.com/science/article/pii/S1935861X14003180Brain stimulationSuctionSwallowingElectromyographytDCSDysphagia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giuseppe Cosentino Enrico Alfonsi Filippo Brighina Mauro Fresia Brigida Fierro Giorgio Sandrini Antonio Schindler Francesca Valentino Danilo Fontana Alberto Priori |
spellingShingle |
Giuseppe Cosentino Enrico Alfonsi Filippo Brighina Mauro Fresia Brigida Fierro Giorgio Sandrini Antonio Schindler Francesca Valentino Danilo Fontana Alberto Priori Transcranial Direct Current Stimulation Enhances Sucking of a Liquid Bolus in Healthy Humans Brain Stimulation Brain stimulation Suction Swallowing Electromyography tDCS Dysphagia |
author_facet |
Giuseppe Cosentino Enrico Alfonsi Filippo Brighina Mauro Fresia Brigida Fierro Giorgio Sandrini Antonio Schindler Francesca Valentino Danilo Fontana Alberto Priori |
author_sort |
Giuseppe Cosentino |
title |
Transcranial Direct Current Stimulation Enhances Sucking of a Liquid Bolus in Healthy Humans |
title_short |
Transcranial Direct Current Stimulation Enhances Sucking of a Liquid Bolus in Healthy Humans |
title_full |
Transcranial Direct Current Stimulation Enhances Sucking of a Liquid Bolus in Healthy Humans |
title_fullStr |
Transcranial Direct Current Stimulation Enhances Sucking of a Liquid Bolus in Healthy Humans |
title_full_unstemmed |
Transcranial Direct Current Stimulation Enhances Sucking of a Liquid Bolus in Healthy Humans |
title_sort |
transcranial direct current stimulation enhances sucking of a liquid bolus in healthy humans |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2014-11-01 |
description |
Background: Transcranial direct current stimulation (tDCS) is a non-invasive technique used for modulating cortical excitability in vivo in humans. Here we evaluated the effect of tDCS on behavioral and electrophysiological aspects of physiological sucking and swallowing. Methods: Twelve healthy subjects underwent three tDCS sessions (anodal, cathodal and sham stimulation) on separate days in a double-blind randomized order. The active electrode was placed over the right swallowing motor cortex. Repeated sucking and swallowing acts were performed at baseline and at 15 and 60 min after each tDCS session and the mean liquid bolus volume ingested at each time point was measured. We also calculated average values of the following electrophysiological parameters: 1) area and 2) duration of the rectified EMG signal from the suprahyoid/submental muscles related to the sucking and swallowing phases; 3) EMG peak amplitude for the sucking and swallowing phases; 4) area and peak amplitude of the laryngeal-pharyngeal mechanogram; 5) oropharyngeal delay. Results: The volume of the ingested bolus significantly increased (by an average of about 30% compared with the baseline value) both at 15 and at 60 min after the end of anodal tDCS. The electrophysiological evaluation after anodal tDCS showed a significant increase in area and duration of the sucking phase-related EMG signal. Conclusions: Anodal tDCS leads to stronger sucking of a liquid bolus in healthy subjects, likely by increasing recruitment of cortical areas of the swallowing network. This finding might open up interesting perspectives for the treatment of patients suffering from dysphagia due to various pathological conditions. |
topic |
Brain stimulation Suction Swallowing Electromyography tDCS Dysphagia |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X14003180 |
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