Methadone Inhibits Viral Restriction Factors and Facilitates HIV Infection in Macrophages

Methadone Inhibits Viral Restriction Factors and Facilitates HIV Infection in Macrophages

Opioid abuse alters the functions of immune cells in both in vitro and in vivo systems, including macrophages. Here, we investigated the effects of methadone, a widely used opioid receptor agonist for treatment of opiate addiction, on the expression of intracellular viral restriction factors and HIV...

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Bibliographic Details
Main Authors: Mei-Rong Wang, Di-Di Wu, Fan Luo, Chao-Jie Zhong, Xin Wang, Ni Zhu, Ying-Jun Wu, Hai-Tao Hu, Yong Feng, Xu Wang, Hai-Rong Xiong, Wei Hou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
opioids
HIV
innate immunity
interferons
miRNAs
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01253/full

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